Brain estrogens rapidly strengthen auditory encoding and guide song preference in a songbird.

Proceedings of the National Academy of Sciences of the United States of America
Luke Remage-HealeyBarney A Schlinger

Abstract

Higher cognitive function depends on accurate detection and processing of subtle features of sensory stimuli. Such precise computations require neural circuits to be modulated over rapid timescales, yet this modulation is poorly understood. Brain-derived steroids (neurosteroids) can act as fast signaling molecules in the vertebrate central nervous system and could therefore modulate sensory processing and guide behavior, but there is no empirical evidence for this possibility. Here we report that acute inhibition of estrogen production within a cortical-like region involved in complex auditory processing disrupts a songbird's ability to behaviorally respond to song stimuli. Identical manipulation of local estrogen levels rapidly changes burst firing of single auditory neurons. This acute estrogen-mediated modulation targets song and not other auditory stimuli, possibly enabling discrimination among species-specific signals. Our results demonstrate a crucial role for neuroestrogen synthesis among vertebrates for enhanced sensory encoding. Cognitive impairments associated with estrogen depletion, including verbal memory loss in humans, may therefore stem from compromised moment-by-moment estrogen actions in higher-order cortical ...Continue Reading

References

Feb 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·J CynxF Nottebohm
Apr 11, 1995·Proceedings of the National Academy of Sciences of the United States of America·S J ChewD S Vicario
Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·M S Lewicki, M Konishi
Apr 1, 1994·General and Comparative Endocrinology·J WadeA P Arnold
Oct 29, 1993·Science·M SteriadeT J Sejnowski
Sep 27, 1996·Science·A C Yu, D Margoliash
Feb 13, 2001·Trends in Neurosciences·S M Sherman
Sep 6, 2002·Nature·Richard H R HahnloserMichale S Fee
Aug 9, 2003·Nature·Timothy Q Gentner, Daniel Margoliash
Dec 9, 2003·Nature Reviews. Neuroscience·Rüdiger Krahe, Fabrizio Gabbiani
Jan 27, 2004·NeuroImage·Jamie L EberlingWilliam J Jagust
Aug 20, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Melissa J Coleman, R Mooney
Aug 13, 2005·Psycho-oncology·Catherine M BenderChristopher M Ryan
Sep 30, 2005·Proceedings. Biological Sciences·R Scott PetersonColin J Saldanha
Nov 11, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marnie E HalpernLesley J Rogers
Apr 4, 2006·Trends in Neurosciences·Jacques Balthazart, Gregory F Ball
Jun 9, 2006·Nature Reviews. Neuroscience·Johan J Bolhuis, Manfred Gahr
Jul 21, 2006·Brain Research·Luke Remage-Healey, Andrew H Bass
Aug 22, 2006·Annual Review of Pharmacology and Toxicology·Catherine S Woolley
Oct 3, 2006·Annual Review of Physiology·Eve Marder, Dirk Bucher
Apr 17, 2007·Current Biology : CB·Sharon M H Gobes, Johan J Bolhuis
Jun 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·Henning U VossSantosh A Helekar
Sep 15, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Melissa J ColemanRichard Mooney
Oct 18, 2007·Proceedings of the National Academy of Sciences of the United States of America·Stefan Remy, Nelson Spruston
Feb 8, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Eric E BauerRichard Mooney
Apr 9, 2008·Nature Neuroscience·Sarah E London, David F Clayton
Apr 12, 2008·The Journal of Physiology·Christian WoznyJoachim Behr
May 9, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Richard H R HahnloserKatja Naie
Jul 8, 2008·Journal of Neuroendocrinology·L M Garcia-Segura
Sep 30, 2008·Nature Neuroscience·Luke Remage-HealeyBarney A Schlinger
Dec 5, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mimi H KaoAllison J Doupe
Dec 17, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Susanne WeisWalter Sturm
Apr 21, 2009·Nature Reviews. Neuroscience·Martin SarterW Matthew Howe
May 8, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Liisa A TremereRaphael Pinaud
Jul 1, 2007·Animal : an International Journal of Animal Bioscience·W M RauwL Gómez-Raya

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Citations

Jul 19, 2012·Nature Reviews. Neuroscience·Raphael Pinaud, Liisa A Tremere
Jul 18, 2012·Proceedings of the National Academy of Sciences of the United States of America·Sanne MoormanJohan J Bolhuis
Nov 30, 2012·Proceedings. Biological Sciences·Megan D GallJeffrey R Lucas
Apr 18, 2012·Endocrinology·Charlotte A CornilColin J Saldanha
May 31, 2011·Endocrine Reviews·Colin J SaldanhaBarney A Schlinger
Jul 8, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Luke Remage-HealeyBarney A Schlinger
Jun 16, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Luke Remage-Healey, Narendra R Joshi
Jan 4, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Aurore L SeredynskiCharlotte A Cornil
Nov 16, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Liisa A TremereRaphael Pinaud
Dec 12, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Melissa L CarasEdwin W Rubel
Mar 4, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Liisa A Tremere, Raphael Pinaud
Jul 6, 2014·PloS One·Jason A MirandaRobert C Liu
Apr 15, 2014·General and Comparative Endocrinology·Barney A SchlingerMichelle Rensel
Apr 2, 2014·Frontiers in Neuroendocrinology·Sarah A LaredoBrian C Trainor
Jul 19, 2014·Neuroscience and Biobehavioral Reviews·Sanne Moorman, Alister U Nicol
Aug 6, 2013·Frontiers in Neuroendocrinology·Melissa L Caras
Apr 30, 2013·Frontiers in Neuroendocrinology·Barney A SchlingerMatthew J Fuxjager
Sep 18, 2012·Frontiers in Neuroendocrinology·Charlotte A CornilJacques Balthazart
Feb 22, 2012·The Journal of Steroid Biochemistry and Molecular Biology·Deepak P Srivastava
Sep 6, 2011·Trends in Endocrinology and Metabolism : TEM·Iñigo AzcoitiaLuis M Garcia-Segura
Sep 11, 2010·Current Opinion in Neurobiology·Darcy B Kelley, Andrew H Bass
Mar 1, 2016·Journal of Ornithology·Barney A Schlinger
Dec 29, 2015·Journal of Neurochemistry·Devon ComitoBarney A Schlinger
May 4, 2011·Journal of Neuroendocrinology·B A Schlinger, L Remage-Healey
Aug 21, 2010·Journal of Neurochemistry·Devaleena S PradhanKiran K Soma
Jul 1, 2011·The European Journal of Neuroscience·Lisa L MatragranoDonna L Maney
Oct 16, 2012·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Luke Remage-Healey
Jun 12, 2013·Journal of Neuroendocrinology·L Remage-HealeyN R Joshi
Aug 26, 2014·The European Journal of Neuroscience·F MenardyC Del Negro
Sep 11, 2014·Developmental Neurobiology·Andrew ChaoLuke Remage-Healey
Sep 16, 2014·Developmental Neurobiology·Kathleen M YoderDavid S Vicario
Sep 17, 2013·Hearing Research·David RothenbergOfer Tchernichovski

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