Brain function early after stroke in relation to subsequent recovery

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Hoang NhanS C Cramer

Abstract

This study aimed to characterize brain activation and perfusion early after stroke within cortical regions that would later change activation during recovery. Patients were studied serially after stroke (mean t1, = 16 days after stroke, t2 = 3.5 months later) using perfusion-weighted imaging and functional magnetic resonance imaging during finger movement. Controls (n = 7) showed no significant change in regional activation volumes over time. Among stroke patients (n = 8), however, recovery was accompanied by several patterns of functional magnetic resonance imaging change, with increased activation volumes over time in five patients and decreased in two. Most regions increasing activation over time were in the stroke hemisphere. Of the five patients showing increased activation over time, specific activation foci enlarged at t2 were already activated at t1 in four patients, and at least one focus growing from t1 to t2 was in a different arterial distribution from the infarct in all five patients. Perfusion of sensorimotor cortex at t1 was generally not reduced in the stroke hemisphere (94% of noninfarcted hemisphere). Improved clinical outcome was related to increased activation within sensory cortices of both brain sides, inc...Continue Reading

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Citations

Oct 3, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Nuray Yozbatiran, Steven C Cramer
Feb 13, 2013·Journal of Neurologic Physical Therapy : JNPT·Alexandra L BorstadDeborah S Nichols-Larsen
Dec 3, 2011·Neural Plasticity·Jonas A Hosp, Andreas R Luft
May 2, 2012·Neural Plasticity·Annette Sterr, Adriana Bastos Conforto
Mar 24, 2015·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Yukihiro Hara
Jan 1, 2010·PET Clinics·James M Mountz
Jan 20, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Randolph S MarshallJoy Hirsch
Mar 16, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Kenneth M SicardCraig F Ferris
Dec 1, 2015·Frontiers in Neurology·Rüdiger J Seitz, Geoffrey A Donnan
Dec 20, 2005·Neuroimaging Clinics of North America·Craig D TakahashiSteven C Cramer
May 2, 2006·Journal of Magnetic Resonance Imaging : JMRI·Cornelius WeillerMichel Rijntjes
Oct 1, 2010·Journal of Magnetic Resonance Imaging : JMRI·Rüdiger J Seitz, Geoffrey A Donnan
Jun 4, 2011·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Christian Xerri
Jan 8, 2005·Stroke; a Journal of Cerebral Circulation·Jean-Claude Baron, Steven Warach
Jul 20, 2019·Neurorehabilitation and Neural Repair·Morgan L IngemansonSteven C Cramer
Sep 1, 2016·Translational Stroke Research·Emiri T MandevilleJoseph B Mandeville

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