Brain functional abnormality in schizo-affective disorder: an fMRI study

Psychological Medicine
M MadreBenedikt Amann

Abstract

Schizo-affective disorder has not been studied to any significant extent using functional imaging. The aim of this study was to examine patterns of brain activation and deactivation in patients meeting strict diagnostic criteria for the disorder. Thirty-two patients meeting research diagnostic criteria (RDC) for schizo-affective disorder (16 schizomanic and 16 schizodepressive) and 32 matched healthy controls underwent functional magnetic resonance imaging (fMRI) during performance of the n-back task. Linear models were used to obtain maps of activations and deactivations in the groups. Controls showed activation in a network of frontal and other areas and also deactivation in the medial frontal cortex, the precuneus and the parietal cortex. Schizo-affective patients activated significantly less in prefrontal, parietal and temporal regions than the controls, and also showed failure of deactivation in the medial frontal cortex. When task performance was controlled for, the reduced activation in the dorsolateral prefrontal cortex (DLPFC) and the failure of deactivation of the medial frontal cortex remained significant. Schizo-affective disorder shows a similar pattern of reduced frontal activation to schizophrenia. The disorder i...Continue Reading

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Citations

Aug 13, 2013·PloS One·Sean P DavidJohn P A Ioannidis
Jul 19, 2015·Schizophrenia Bulletin·Ramón Landin-RomeroJoaquim Radua
Aug 2, 2015·Journal of Affective Disorders·Ramón Landin-RomeroJoaquim Radua
Jul 9, 2013·Journal of Affective Disorders·Cristian VargasEduard Vieta
Feb 18, 2016·The Australian and New Zealand Journal of Psychiatry·Ramón Landin-RomeroBenedikt L Amann

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