Brain Functional and Structural Signatures in Parkinson's Disease

Frontiers in Aging Neuroscience
Chunhua LiuChuantao Zuo

Abstract

The aim of this study is to explore functional and structural properties of abnormal brain networks associated with Parkinson's disease (PD). 18F-Fluorodeoxyglucose positron emission tomography (18F-FDG PET) and T1-weighted magnetic resonance imaging from 20 patients with moderate-stage PD and 20 age-matched healthy controls were acquired to identify disease-related patterns in functional and structural networks. Dual-modal images from another prospective subject of 15 PD patients were used as the validation group. Scaled Subprofile Modeling based on principal component analysis method was applied to determine disease-related patterns in both modalities, and brain connectome analysis based on graph theory was applied to verify these patterns. The results showed that the expressions of the metabolic and structural patterns in PD patients were significantly higher than healthy controls (PD1-HC, p = 0.0039, p = 0.0058; PD2-HC, p < 0.001, p = 0.044). The metabolic pattern was characterized by relative increased metabolic activity in pallidothalamic, pons, putamen, and cerebellum, associated with metabolic decreased in parietal-occipital areas. The structural pattern was characterized by relative decreased gray matter (GM) volume in...Continue Reading

References

Mar 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·A J HughesA J Lees
Oct 1, 1991·Brain : a Journal of Neurology·J M Fearnley, A J Lees
Dec 13, 2002·Brain : a Journal of Neurology·Lars TimmermannAlfons Schnitzler
Dec 25, 2002·Neurobiology of Aging·Heiko BraakEva Braak
Sep 1, 2004·Cell and Tissue Research·Heiko BraakKelly Del Tredici
Jun 29, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yilong MaDavid Eidelberg
May 2, 2007·Brain : a Journal of Neurology·Chaorui HuangDavid Eidelberg
Apr 18, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shigeki HiranoDavid Eidelberg
Sep 24, 2008·Handbook of Clinical Neurology·Thomas Wichmann, Mahlon R Delong
Nov 18, 2008·Neurobiology of Disease·Kathleen L Poston, David Eidelberg
Jun 6, 2009·Current Opinion in Neurology·Adam ZaidelHagai Bergman
Sep 21, 2010·Behavioural Brain Research·Feng BaiZhijun Zhang
Dec 17, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chun-Yi LoChing-Po Lin
Dec 28, 2010·NeuroImage·Thomas JubaultOury Monchi
Aug 25, 2011·Journal of the Neurological Sciences·Roberta BiundoAngelo Antonini
Apr 28, 2012·AJNR. American Journal of Neuroradiology·A TessitoreG Tedeschi
Feb 23, 2013·Proceedings of the National Academy of Sciences of the United States of America·Bong-Kyu ChoiYeon-Kyun Shin
Jul 16, 2013·Journal of Visualized Experiments : JoVE·Phoebe SpetsierisDavid Eidelberg
Mar 19, 2014·Human Brain Mapping·Hugo-Cesar BaggioCarme Junqué
Nov 12, 2014·Nature Reviews. Neurology·Marios Politis
Sep 8, 2015·ELife·Yashar ZeighamiAlain Dagher
Jan 2, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Dmitry TitovIgor Yakushev
Nov 22, 2016·Brain Research·Huoqiang DuanUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Apr 13, 2017·Neurobiology of Disease·Emily M RochaLaurie H Sanders
Nov 1, 2017·Cerebral Cortex·Ji Hyun KoDavid Eidelberg
Jan 13, 2018·Heliyon·Jiehui JiangUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jun 20, 2018·Lancet Neurology·Katharina A Schindlbeck, David Eidelberg
Dec 24, 2018·The New England Journal of Medicine·Michael D Fox
Jan 27, 2019·Journal of the Neurological Sciences·Heather WilsonMarios Politis

❮ Previous
Next ❯

Methods Mentioned

BETA
PCA

Software Mentioned

Matlab2016b
ScanVP
Statistical Parametric Mapping
Brain Connectivity Toolbox
Graph Analysis Toolbox

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.