Abstract
The effect of 4 weeks of spontaneous chronic ethanol intake in drinking water and then ethanol withdrawal on the gamma-aminobutyric acid (GABA) steady-state levels and turnover rates was investigated in 15 brain areas of C57 Bl/6J alcohol-preferring mice. These mice did not display typical ethanol withdrawal convulsions. There was no statistically significant difference in the brain GABA steady-state levels among the control group, chronic ethanol-treated mice, and mice after ethanol withdrawal. In contrast, chronic ethanol treatment induced significant variations in GABA turnover rate, as measured by gabaculine-induced accumulation of GABA, in eight of 15 areas examined versus a decrease in seven brain areas [cerebellum (-29%), amygdala (-28%), olfactory tubercles (-24%), septum (-24%), striatum (-53%), frontal cortex (-21%), and hippocampus (-24%)]; an increase in turnover rate in the posterior colliculus (100%) was observed. At 26 h after ethanol withdrawal, in the seven areas in which GABA turnover rate decreased after spontaneous chronic ethanol intake, a return to the initial control value was observed; in the posterior colliculus, the turnover rate did not change, remaining higher than the control value. This persisting ...Continue Reading
References
Oct 18, 1977·Biochemistry·R R Rando
Mar 16, 1976·Psychopharmacologia·E P NobleP Mandel
Sep 11, 1977·Journal of Chromatography·R Schmid, M Karobath
Oct 1, 1975·Neuropharmacology·M E Hillbom
Jul 1, 1975·Journal of Neurochemistry·I A SytinskyN N Konovalova
Jul 1, 1985·Journal of Neurochemistry·L CiesielskiP Mandel
Jan 1, 1985·Pharmacology, Biochemistry, and Behavior·M S Dar, W R Wooles
Aug 1, 1974·Life Sciences·D B Goldstein, R Kakihana
Apr 16, 1971·Science·D B Goldstein, N Pal
Jan 1, 1983·Pharmacology, Biochemistry, and Behavior·W A Hunt, E Majchrowicz
Nov 1, 1984·Alcohol·M S Dar, W R Wooles
Feb 1, 1980·Journal of Neurochemistry·M K Ticku, T Burch
Mar 1, 1984·Alcohol·C S Lieber
Sep 7, 1984·Neuroscience Letters·L LescaudronR Jaffard
Nov 19, 1984·Life Sciences·J D McSwiganE R Young
Feb 1, 1983·Pharmacology, Biochemistry, and Behavior·W J Millard, V P Dole
Jan 1, 1982·Journal of Neurochemistry·R BernasconiF Raschdorf
Jan 1, 1982·Pharmacology, Biochemistry, and Behavior·S SimlerP Mandel
Sep 22, 1980·Life Sciences·P Supavilai, M Karobath
Aug 1, 1960·Proceedings of the Society for Experimental Biology and Medicine·V RILEY
Apr 1, 1962·Biochemical Pharmacology·E S HIGGINS
Citations
Sep 1, 1989·Physiology & Behavior·L P Gonzalez, J F Czachura
Aug 1, 1987·Pharmacology, Biochemistry, and Behavior·A M Allan, R A Harris
Jan 1, 1992·Pharmacology, Biochemistry, and Behavior·S RouhaniS Poenaru
Jan 1, 1984·Experimental Pathology·K Dietzmann, L M Gershtein
Aug 1, 1990·Alcoholism, Clinical and Experimental Research·B H HwangT K Li
Aug 19, 2003·Comparative Hepatology·Patrizia PagliaraLuciana Dini
Oct 4, 2012·Toxicology and Industrial Health·Sarmishtha ChatterjeeShelley Bhattacharya
Oct 6, 1992·Biochemical Pharmacology·M BidderM Gavish
Jan 1, 1997·Addiction Biology·N P KanunnikovaS M Zimatkin