PMID: 3772386Dec 1, 1986Paper

Brain gamma-aminobutyric acid turnover rates after spontaneous chronic ethanol intake and withdrawal in discrete brain areas of C57 mice

Journal of Neurochemistry
S SimlerP Mandel

Abstract

The effect of 4 weeks of spontaneous chronic ethanol intake in drinking water and then ethanol withdrawal on the gamma-aminobutyric acid (GABA) steady-state levels and turnover rates was investigated in 15 brain areas of C57 Bl/6J alcohol-preferring mice. These mice did not display typical ethanol withdrawal convulsions. There was no statistically significant difference in the brain GABA steady-state levels among the control group, chronic ethanol-treated mice, and mice after ethanol withdrawal. In contrast, chronic ethanol treatment induced significant variations in GABA turnover rate, as measured by gabaculine-induced accumulation of GABA, in eight of 15 areas examined versus a decrease in seven brain areas [cerebellum (-29%), amygdala (-28%), olfactory tubercles (-24%), septum (-24%), striatum (-53%), frontal cortex (-21%), and hippocampus (-24%)]; an increase in turnover rate in the posterior colliculus (100%) was observed. At 26 h after ethanol withdrawal, in the seven areas in which GABA turnover rate decreased after spontaneous chronic ethanol intake, a return to the initial control value was observed; in the posterior colliculus, the turnover rate did not change, remaining higher than the control value. This persisting ...Continue Reading

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Citations

Sep 1, 1989·Physiology & Behavior·L P Gonzalez, J F Czachura
Aug 1, 1987·Pharmacology, Biochemistry, and Behavior·A M Allan, R A Harris
Jan 1, 1992·Pharmacology, Biochemistry, and Behavior·S RouhaniS Poenaru
Aug 1, 1990·Alcoholism, Clinical and Experimental Research·B H HwangT K Li
Aug 19, 2003·Comparative Hepatology·Patrizia PagliaraLuciana Dini
Oct 4, 2012·Toxicology and Industrial Health·Sarmishtha ChatterjeeShelley Bhattacharya
Jan 1, 1997·Addiction Biology·N P KanunnikovaS M Zimatkin

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