Brain glucose and lactate levels during ventilator-induced hypo- and hypercapnia

Clinical Physiology and Functional Imaging
Robert A van HulstBurkhard Lachmann

Abstract

Levels of glucose and lactate were measured in the brain by means of microdialysis in order to evaluate the effects of ventilator-induced hypocapnia and hypercapnia on brain metabolism in healthy non-brain-traumatized animals. Prospective animal study in a university laboratory. Eight adult Landrace/Yorkshire pigs. The microdialysis probe was inserted in the brain along with a multiparameter sensor and intracranial pressure (ICP) probe. The animals were ventilated in a pressure-controlled mode according to the open lung concept with an inspired oxygen fraction of 0.4/1.0. Starting at normoventilation (PaCO(2) +/-40 mmHg) two steps of both hypercapnia (PCO(2) +/- 70 and 100 mmHg) and hypocapnia (PaCO(2) +/- 20 and 30 mmHg) were performed. Under these conditions, brain glucose and lactate levels as well as brain oxygen (PbrO(2)), brain carbon dioxide (PbrCO(2)), brain pH (brpH), brain temperature and ICP were measured. At hypercapnia (PaCO(2) = 102.7 mmHg) there were no significant changes in brain glucose and lactate but there was a significant increase in PbrCO(2), PbrO(2) and ICP. In contrast, at hypocapnia (PCO(2) = 19.8 mmHg) there was a significant increase in brain lactate and a significant decrease in both brain glucose a...Continue Reading

References

Feb 1, 1979·Journal of Neurochemistry·A B KliefothM E Raichle
Jan 1, 1992·Intensive Care Medicine·B Lachmann
May 1, 1987·Acta paediatrica Scandinavica·G GreisenH Lou
Jun 1, 1980·Anesthesiology·B K Siesjö
Jan 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S P Yang, J A Krasney
Dec 1, 1994·American Journal of Respiratory and Critical Care Medicine·F Feihl, C Perret
May 30, 1998·Anesthesiology·J E Brian
Sep 17, 1998·The New England Journal of Medicine·V L Hood, R L Tannen
Mar 31, 1999·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·L Hillered, L Persson
Oct 16, 1999·Lancet·J G Laffey, B P Kavanagh
Jan 15, 2000·Acta Neurochirurgica. Supplement·P B LetarteD W Marion
Aug 17, 2000·Intensive Care Medicine·S M PeerdemanW P Vandertop
Sep 29, 2000·Critical Care Medicine·J A Carmona SuazoC J Avezaat

❮ Previous
Next ❯

Citations

Feb 19, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Christopher K WilliePhilip N Ainslie
Feb 28, 2008·The Journal of Trauma·Keir J WarnerEileen M Bulger
Sep 28, 2007·Anesthesia and Analgesia·Iain K Moppett, Jonathan G Hardman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.