Brain glucose metabolism in Lewy body dementia: implications for diagnostic criteria

Alzheimer's Research & Therapy
Silvia Paola CaminitiDaniela Perani

Abstract

[18F]FDG-PET hypometabolism patterns are indicative of different neurodegenerative conditions, even from the earliest disease phase. This makes [18F]FDG-PET a valuable tool in the diagnostic workup of neurodegenerative diseases. The utility of [18F]FDG-PET in dementia with Lewy bodies (DLB) needs further validation by considering large samples of patients and disease comparisons and applying state-of-the-art statistical methods. Here, we aimed to provide an extensive validation of the [18F]FDG-PET metabolic signatures in supporting DLB diagnosis near the first clinical assessment, which is characterized by high diagnostic uncertainty, at the single-subject level. In this retrospective study, we included N = 72 patients with heterogeneous clinical classification at entry (mild cognitive impairment, atypical parkinsonisms, possible DLB, probable DLB, and other dementias) and an established diagnosis of DLB at a later follow-up. We generated patterns of [18F]FDG-PET hypometabolism in single cases by using a validated voxel-wise analysis (p < 0.05, FWE-corrected). The hypometabolism patterns were independently classified by expert raters blinded to any clinical information. The final clinical diagnosis at follow-up (2.94 ± 1.39 [0....Continue Reading

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Jul 20, 2019·Human Brain Mapping·Arianna SalaDaniela Perani
Dec 8, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Arianna SalaDaniela Perani
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Methods Mentioned

BETA
PCA

Software Mentioned

DaTSCAN
SPM5
Matlab
SPM
RStudio

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