Brain glucose: voltammetric determination in normal and hyperglycaemic rats using a glucose microsensor

Neuroreport
N F ShramR Cespuglio

Abstract

Pulsed voltammetry applied to glucose oxidase-coated carbon fibre electrodes (glucose sensor) was used for brain glucose determination in normal and streptozotocin-treated rats (experimental diabetes mellitus). Glucose levels increased in the frontal cortex of diabetic animals compared with the controls (+262%). Glucose levels were also increased in their CSF (+48%) and plasma (+64%), determined in ex vivo conditions. The validity of the glucose sensor determinations, as well as that of the experimental model of diabetes used, was checked using the Beckman glucose analyser and a radioimmunoassay for plasma insulin. Insulin, unlike glucose, was decreased in diabetic animals. The sensor described here ensures precise determinations and is suitable for use in experimental models where alterations in glucose metabolism occur.

References

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Citations

Apr 12, 2001·The European Journal of Neuroscience·L NetchiporoukR Cespuglio
May 28, 2010·Journal of Neurotrauma·Julia HillPramod K Dash
Apr 17, 2010·ASN Neuro·Gautam K GandhiGerald A Dienel
Sep 22, 2020·Journal of Caffeine and Adenosine Research·David N RuskinSusan A Masino
May 28, 2019·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Fernando MartínezFrancisco Nualart
May 17, 2014·Metabolic Brain Disease·Aarti NagayachIshan Patro
Jun 18, 2015·Journal of Cellular and Molecular Medicine·Roberto Elizondo-VegaMaria A García-Robles
Jan 20, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ruth B S Harris
May 26, 2018·Molecular Neurobiology·A J López-GamberoF Nualart
Nov 20, 2014·Frontiers in Cellular Neuroscience·Giselle CheungNathalie Rouach
Dec 4, 2012·International Journal of Molecular Sciences·Kaushik ShahThomas Abbruscato
Aug 30, 2014·Journal of Lipid Research·Masahito KawamuraSusan A Masino
May 2, 2019·Frontiers in Endocrinology·Roberto Javier Elizondo-VegaKarina Oyarce
May 22, 2021·Purinergic Signalling·Magdiel SalgadoJuan C Sáez

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