PMID: 634355Mar 23, 1978

Brain histamine receptors as targets for antidepressant drugs

P D Kanof, P Greengard


A large number of structurally diverse drugs with clinical antidepressant properties share the ability to act as potent inhibitors of histamine-sensitive adenylate cyclase in cell-free preparations from mammalian brain. This common biochemical action may represent part of the molecular basis for the antidepressant properties of these compounds.


Mar 11, 1976·Nature·L R HegstrandP Greengard
Feb 1, 1977·Archives of General Psychiatry·S H Snyder, H I Yamamura
Jul 1, 1977·Archives of Biochemistry and Biophysics·P D KanofP Greengard
Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·J P GreenS Maayani
Jan 1, 1977·Annual Review of Pharmacology and Toxicology·J C Schwartz
Jun 19, 1975·Nature·Helmut L Haas, U M Bucher
Mar 7, 1977·European Journal of Pharmacology·K GhoseJ Lund
Jul 1, 1977·Clinical Pharmacokinetics·L F Gram
Oct 1, 1977·British Journal of Pharmacology·I GoodletM F Sugrue
Oct 1, 1976·The British Journal of Psychiatry : the Journal of Mental Science·A CoppenJ J de Ridder
Apr 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·Y C Clement-CormierP Greengard
Jan 1, 1973·Annual Review of Pharmacology·J J Schildkraut
Jan 1, 1966·Acta Pharmacologica Et Toxicologica·S B Ross, A L Renyi
Aug 1, 1966·British Journal of Pharmacology and Chemotherapy·A S Ash, H O Schild
Jul 1, 1967·Life Sciences·S B Ross, A L Renyl
Jan 1, 1969·International Journal of Neuropharmacology·A BarnettF E Roth
Apr 21, 1972·Nature·J W BlackE M Parsons
Dec 13, 1974·Nature·K Von HungenD F Hill
Mar 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·J A Nathanson, P Greengard
Dec 1, 1972·American Industrial Hygiene Association Journal·B A Johnson
Sep 1, 1967·The British Journal of Psychiatry : the Journal of Mental Science·N K el-DeiryS K Littmann
Jan 1, 1969·Clinical Pharmacology and Therapeutics·J E OVERALLV Pennington
Mar 1, 1972·Journal of Neurochemistry·J C SchwartzC Rose
Sep 1, 1972·Archives of General Psychiatry·G M SimpsonJ H Lee
Feb 1, 1972·Archives of General Psychiatry·W E FannJ A Oates
Sep 1, 1972·Journal of Psychiatric Research·A Coppen
Nov 1, 1965·The American Journal of Psychiatry·J J Schildkraut
Apr 7, 1967·Science·J J Schildkraut, S S Kety
Sep 1, 1969·European Journal of Pharmacology·S B Ross, A L Renyi
Aug 24, 1964·JAMA : the Journal of the American Medical Association·J E OVERALLJ SHELTON


Jan 1, 1982·Journal of Neurobiology·R B ChronisterJ I Hubbard
Jan 1, 1980·Psychopharmacology·J D ElsworthM Sandler
Dec 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·A Walland
Apr 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·S W Tang, P Seeman
Jul 1, 1983·Biulleten' eksperimental'noĭ biologii i meditsiny·V V RozhanetsA V Val'dman
Jan 1, 1990·Journal of Neural Transmission. General Section·J C FolanC Heym
Dec 1, 1989·Digestive Diseases and Sciences·D E Hernandez
Jan 1, 1978·Journal of Neural Transmission·A Carlsson, M Lindqvist
Oct 20, 1989·Pharmaceutisch Weekblad. Scientific Edition·H Timmerman
Jul 1, 1982·Agents and Actions·T J Rising, S Lewis
Nov 1, 1986·Agents and Actions·I R SmithM E Mylek
Nov 1, 1980·Agents and Actions·I R SmithK M Metters
Oct 29, 2011·Naunyn-Schmiedeberg's Archives of Pharmacology·Heidrun ApplRoland Seifert
Dec 15, 1982·Biochemical Pharmacology·L B HoughJ P Green
Oct 3, 1980·European Journal of Pharmacology·J E Taylor, E Richelson
Jul 11, 1980·European Journal of Pharmacology·P A Brown, J Vernikos
Mar 26, 1981·European Journal of Pharmacology·H Hall, S O Ogren
Oct 28, 1983·European Journal of Pharmacology·S Kanba, E Richelson
Sep 11, 1979·Life Sciences·J C Schwartz
Sep 20, 1982·Life Sciences·R BluhmA P Winnie
May 1, 1980·Neuropharmacology·M M Sellinger-BarnetteA Frazer
Jun 1, 1982·Physiology & Behavior·E O Alvarez, F A Guerra
Mar 1, 1981·Pharmacology, Biochemistry, and Behavior·I M Mazurkiewicz-Kwilecki
Jan 1, 1984·Pharmacology, Biochemistry, and Behavior·S K Rastogi, D E McMillan
May 1, 1995·Pharmacology, Biochemistry, and Behavior·P GhiP Portaleone
Oct 1, 1984·Journal of Affective Disorders·K WoodA Coppen
Jan 1, 1981·Progress in Neurobiology·S T Mason
Apr 8, 2003·European Journal of Pharmacology·Thomas Roeder
Jul 25, 1998·Pharmacology, Biochemistry, and Behavior·R DirksenC M Van Rijn
Jan 1, 1982·Progress in Neuro-psychopharmacology & Biological Psychiatry·G Kato, T Ban
May 13, 1999·Ultrasound in Medicine & Biology·A B WrightE J Post
Sep 5, 2002·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Bogusława Pietrzak, Elzbieta Kubik-Bogucka
Dec 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·V T TranS H Snyder
Jan 1, 1981·Pharmacology & Therapeutics·M F Sugrue
Jul 1, 1985·The International Journal of Neuroscience·J A Jesberger, J S Richardson
Jan 1, 1988·Scandinavian Journal of Gastroenterology. Supplement·M Tryba, K Kurz-Muller
Jan 1, 1981·Scandinavian Journal of Gastroenterology·M G Moshal, F Khan
Jan 1, 1980·Current Medical Research and Opinion·W P TormeyA Darragh
Dec 1, 1982·Psychological Reports·J B Murray
Dec 19, 2006·The Journal of Pain : Official Journal of the American Pain Society·Ivy E DickBirgit T Priest
Dec 1, 1982·Medical Hypotheses·J C Newman
Jan 1, 1979·Comprehensive Psychiatry·L Eisenberg
Mar 1, 1980·British Journal of Pharmacology·P R GoldsP G Strange
Jan 1, 1983·British Journal of Clinical Pharmacology·J A WilsonK G Wormsley
Jan 1, 1983·British Journal of Clinical Pharmacology·R M Pinder, A M van Delft
Jan 1, 1983·British Journal of Clinical Pharmacology·R J Marshall
Jun 1, 1985·Australian and New Zealand Journal of Medicine·A J McLeanF J Dudley
Jan 1, 1983·Acta Psychiatrica Scandinavica. Supplementum·R M Pinder, A M van Delft
Jul 1, 1980·Journal of Neurochemistry·J C SchwartzT T Quach
Jan 1, 1985·Acta Psychiatrica Scandinavica. Supplementum·J A WilsonK G Wormsley
Jan 1, 1981·Acta Psychiatrica Scandinavica. Supplementum·S O OgrenA L Renyi
Jan 1, 1988·British Journal of Pharmacology·C R CalcuttR C Young
Feb 1, 1982·British Journal of Urology·K E Creed, A G Tulloch
Jan 1, 1982·Progress in Neuro-psychopharmacology & Biological Psychiatry·P SavardA Dupont
Jan 1, 1982·Progress in Neuro-psychopharmacology & Biological Psychiatry·M A GagneG Pinard
May 13, 2004·Regional Anesthesia and Pain Medicine·Danja Strumper, Marcel E Durieux
Dec 1, 1979·Biochemical Pharmacology·A Biegon, D Samuel
Jan 1, 1982·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P M Gross
Jul 16, 2008·Physiological Reviews·Helmut L HaasOliver Selbach
Aug 1, 1986·The British Journal of Psychiatry : the Journal of Mental Science·N S Harvey, W I Mikhail
Aug 1, 1984·The British Journal of Psychiatry : the Journal of Mental Science·T H CornS A Checkley
Feb 1, 1982·The British Journal of Psychiatry : the Journal of Mental Science·E Shur, S A Checkley
Mar 1, 1981·The British Journal of Psychiatry : the Journal of Mental Science·S A CheckleyS Dawling
Nov 1, 1986·British Journal of Pharmacology·J W BlackN P Shankley
Apr 1, 1987·Alimentary Pharmacology & Therapeutics·W BeilK F Sewing
Nov 1, 1984·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·J J RaymondS Nag
Apr 1, 1994·Alimentary Pharmacology & Therapeutics·W C OrrM H Mellow
Jan 1, 1985·Acta Pharmacologica Et Toxicologica·S O OgrenM F Celani
Jul 1, 1980·Acta Pharmacologica Et Toxicologica·R KlysnerS Norn
Jan 1, 1985·Acta Pharmacologica Et Toxicologica·G N PandeyJ M Davis

Related Concepts

Adenylate Cyclase
Tricyclic Antidepressive Agents
Biogenic Amines
Enzyme Activation
Cavia porcellus
RIMA (Reversible Inhibitor of Monoamine Oxidase A)
Histamine Receptor
Structure-Activity Relationship

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.