PMID: 634355Mar 23, 1978

Brain histamine receptors as targets for antidepressant drugs

Nature
P D Kanof, P Greengard

Abstract

A large number of structurally diverse drugs with clinical antidepressant properties share the ability to act as potent inhibitors of histamine-sensitive adenylate cyclase in cell-free preparations from mammalian brain. This common biochemical action may represent part of the molecular basis for the antidepressant properties of these compounds.

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Related Concepts

Adenylate Cyclase
Tricyclic Antidepressive Agents
Biogenic Amines
Brain
Enzyme Activation
Cavia porcellus
Ceplene
RIMA (Reversible Inhibitor of Monoamine Oxidase A)
Histamine Receptor
Structure-Activity Relationship

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