Brain homovanillic acid: regional changes over time with antipsychotic drugs

European Journal of Pharmacology
M B Bowers, A Rozitis

Abstract

Acute administration of equivalent doses of either chlorpromazine, thioridazine, or clozapine, respectively, produced progressively smaller increases in brain homovanillic acid (HVA) in the rabbit; however, changes in HVA in three brain regions were of equal magnitude for a single dose of a given drug. Chronic administration of fluphenazine enanthate resulted in a decrease in HVA relative to acute treatment in caudate more than limbic regions. No differences between caudate and limbic regions were observed during daily chlorpromazine administration for 3 ro 8 days. Tolerance appeared to develop in approximately 1 week. Chronic treatment with clozapine produced no tolerance at one week but suggestive evidence of tolerance in caudate and limbic regions at two weeks. No tolerance was observed in the hypothalamus during chronic treatment with any drug used. Cisternal CSF HVA paralleled caudate HVA during acute and chronic treatments.

References

Apr 1, 1973·The Journal of Pharmacy and Pharmacology·N E Andén, G Stock
May 1, 1974·The British Journal of Psychiatry : the Journal of Mental Science·P J BeumontD H Wiles
Jan 11, 1974·Psychopharmacologia·I Moller NielsenM Nymark
Feb 1, 1970·British Journal of Pharmacology·R O'KeeffeM Vogt

Citations

Jan 1, 1989·Psychopharmacology·D M CowardT G White
Jan 1, 1994·Journal of Neural Transmission. General Section·A ThielE Rüther
Aug 15, 1977·European Journal of Pharmacology·M Stanley, S Wilk
Mar 1, 1980·Neuropharmacology·G V RebecK D Alloway
Nov 1, 1990·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·S GalderisiD Kemali
Jan 1, 1990·Acta Psychiatrica Scandinavica. Supplementum·P Seeman
Nov 1, 1981·Acta Psychiatrica Scandinavica·G ChouinardR Collu

Related Concepts

Metazoa
Brain
Caudate Nucleus Structure
Thorazine
Leponex
Drug Tolerance
Lyogen
Homovanillic Acid
Organum Vasculosum Laminae Terminalis
Limbic System

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.