Brain Hyperconnectivity >10 Years After Cisplatin-Based Chemotherapy for Testicular Cancer

Brain Connectivity
Myrle M Stouten-KempermanSanne B Schagen

Abstract

Chemotherapy for testicular cancer (TC) has been associated with neurotoxic effects shortly post-treatment. Late effects of chemotherapy on brain function in this patient group are still unknown. In this study, we investigated differences between patients with and without chemotherapy in functional brain networks at rest and during an affective processing functional magnetic resonance imaging (fMRI) task on average >14 years post-treatment. In addition, we report on changes in cognitive functioning during survivorship by comparing present and previous performance on a neuropsychological test battery on average 11 years earlier (3 years post-treatment). Twenty-eight chemotherapy (43.1 ± 7.5 years) and 23 surgery-only (48.2 ± 9.5 years) TC survivors were examined using neurocognitive tests and 3T-fMRI >10 years after treatment end. Brain functional networks were identified using dual regression independent component analysis. Task fMRI was analyzed using a block design. Standardized domain change scores were calculated for each individual to assess cognitive change. TC patients in the chemotherapy group showed functional hyperconnectivity at rest in the precuneus network, sensory and motor function network, executive control netw...Continue Reading

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Citations

Oct 24, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Hayley S WhitfordUNKNOWN Australian and New Zealand Urogenital and Prostate Cancer Trials Group
Aug 30, 2021·Neuroscience and Biobehavioral Reviews·Lori J BernsteinClaude Alain

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Software Mentioned

fMRI
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FEAT
SPM8 Parametric
SPSS Statistics
FSL
ArtRepair
MarsBaR

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