Brain hyperthermia induced by MDMA (ecstasy): modulation by environmental conditions

The European Journal of Neuroscience
P L Brown, Eugene A Kiyatkin

Abstract

Drugs of abuse, such as 3,4-methylenedioxymethamphetamine (MDMA), often have more powerful effects during states of increased activation and under specific environmental conditions. Because hyperthermia is a major complication of MDMA use and a factor potentiating neurotoxicity, we examined the effects of this drug (9 mg/kg, sc; approximately one-fifth of the known LD(50) in rats) on brain [nucleus accumbens (Nacc) and hippocampus (Hippo)] and muscle (musculus temporalis) temperatures in male rats under conditions that either model human drug use (social interaction with female, warm temperature) or restrict heat dissipation from the brain (chronic occlusion of jugular veins). Under quiet resting conditions at 23 degrees C, MDMA induced a moderate but prolonged hyperthermia. Both NAcc and Hippo showed more rapid and stronger temperature increases than muscle, suggesting metabolic neural activation as a primary cause of brain hyperthermia. During social interaction with a female, brain hyperthermia induced by MDMA was significantly potentiated (+89%). Brain hyperthermia induced by MDMA was also strongly potentiated (+188%) in animals with chronically occluded jugular veins, suggesting impaired cerebral outflow enhances intrabrai...Continue Reading

References

Feb 1, 1991·Pharmacology, Biochemistry, and Behavior·C J GordonD B Miller
Mar 27, 1987·JAMA : the Journal of the American Medical Association·G P DowlingR O Bost
Sep 1, 1966·The American Journal of Physiology·J M Delgado, T Hanai
Mar 1, 1967·Experimental Neurology·J G McElligott, R Melzack
Apr 1, 1983·Circulation Research·L B Rowell
Feb 15, 2000·British Journal of Clinical Pharmacology·R de la TorreJ Camí
Sep 16, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·A GammaD Hell
Apr 20, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·F X VollenweiderM J Baggott
Mar 22, 2002·The Journal of Pharmacology and Experimental Therapeutics·Altaf S DarveshGary A Gudelsky
Jun 19, 2002·Journal of Applied Physiology·Lars NyboNiels H Secher
Aug 3, 2002·The European Journal of Neuroscience·Eugene A KiyatkinRoy A Wise
Sep 5, 2002·Forensic Science International : Synergy·Nele SamynWim J Riedel
Nov 29, 2002·The Journal of Physiology·Lars NyboBodil Nielsen
Apr 15, 2003·Journal of Psychoactive Drugs·Franz X VollenweiderMark Geyer
May 15, 2003·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·James R Lepock
May 15, 2003·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·H S Sharma, P J Hoopes
Jul 19, 2003·Pharmacological Reviews·A Richard GreenM Isabel Colado
Apr 22, 2004·Pharmacology, Biochemistry, and Behavior·Yotam Blech-Hermoni, Eugene A Kiyatkin

❮ Previous
Next ❯

Citations

Jan 11, 2005·Neurotoxicity Research·H G Baumgarten, L Lachenmayer
Apr 13, 2007·European Journal of Applied Physiology·Eugene A Kiyatkin
May 14, 2005·Brain Research. Brain Research Reviews·Eugene A Kiyatkin
Apr 28, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Stefani N Von HubenMichael A Taffe
Jul 27, 2012·Journal of Neurophysiology·Michael G WhiteJohn N Barrett
Jul 29, 2005·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Zivorad MalicevićMarina Jovanović
Dec 29, 2009·Frontiers in Bioscience (Landmark Edition)·Eugene A Kiyatkin
Jul 31, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Eugene A KiyatkinYavin Shaham
Jan 24, 2009·Physiology & Behavior·Valerie B ThompsonJack W Lipton
Dec 19, 2006·Neurotoxicology and Teratology·Brian J Piper
Nov 18, 2005·Drug and Alcohol Dependence·Michael A TaffeSimon N Katner
May 25, 2011·Pharmacology, Biochemistry, and Behavior·N W GilpinM A Taffe
Jul 16, 2011·Pharmacology, Biochemistry, and Behavior·Wael M Y MohamedByron C Jones
Jun 25, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Eugene A KiyatkinYavin Shaham
Sep 20, 2011·Drug and Alcohol Dependence·A C Parrott
Oct 1, 2014·Temperature : Multidisciplinary Biomedical Journal·Andrew C Parrott, Lucy Young
Oct 1, 2014·Temperature : Multidisciplinary Biomedical Journal·Eugene A Kiyatkin, Suelynn Ren
Dec 21, 2010·Pharmacology, Biochemistry, and Behavior·Tomáš PáleníčekCyril Höschl
May 15, 2009·Clinical Pharmacology and Therapeutics·G J DumontR J Verkes
Aug 24, 2012·Journal of Intensive Care Medicine·Guy W Soo Hoo
Apr 26, 2018·Therapeutic Hypothermia and Temperature Management·Fritz-Patrick JahnsGeorg Auzinger
Dec 6, 2017·Frontiers in Psychiatry·Kristýna ŠtefkováTomáš Páleníček
Oct 1, 2014·Temperature : Multidisciplinary Biomedical Journal·Eugene A Kiyatkin
Aug 30, 2016·Biomedical Optics Express·Stefan MusolinoMark R Hutchinson
Oct 1, 2014·Temperature : Multidisciplinary Biomedical Journal·Matthias E Liechti
Jan 23, 2020·Scientific Reports·David PerekopskiyEugene A Kiyatkin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.