Brain imaging: reduced sensitivity of RARE-derived techniques to susceptibility effects

Journal of Computer Assisted Tomography
P ReimerP E Peters

Abstract

Our goal was to evaluate the decreased sensitivity of RARE-derived pulse sequences to susceptibility effects. A variety of RARE-derived T2-weighted fast SE echo (FSE) sequences with echo trains from 6 to 16 were compared with conventional SE (CSE) sequences by means of MRI in phantoms (iron oxides), volunteers (n = 10), and patients (n = 13) with old hemorrhagic brain lesions. All experiments were performed on a 1.5 T clinical MR system (Magnetom SP 4000; Siemens AG, Erlangen, Germany) with constant imaging parameters. Contrast-to-noise ratios (CNRs) of tubes doped with iron oxides at different concentrations and brain areas with physiological iron deposition (red nucleus, substantia nigra) were calculated for CSE and FSE pulse sequences. Areas of old brain hemorrhage were analyzed for lesion conspicuity by blinded analysis with CSE as an internal standard. CNR of iron oxide tubes (TE 90 ms, CSE 45.0 +/- 3.5, FSE 16 echo trains 28.5 +/- 3.1; p < or = 0.01) and iron-containing brain areas decreased with increasing echo trains of FSE sequences. A significantly lower number of old hemorrhagic brain lesions was visible in patients scanned with FSE sequences (6 echo trains: n = 28; 16 echo trains; n = 26) than CSE (n = 40). Our resu...Continue Reading

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Citations

Jul 10, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J H JensenH Yu
Jun 13, 2012·European Radiology·Maria del C Valdés HernándezJoanna M Wardlaw
May 6, 2011·European Journal of Radiology·Yuki KanazawaOsamu Sato
Mar 5, 2016·Japanese Journal of Radiology·Tomonori KandaShigeru Furui
Jun 24, 2008·Academic Radiology·Christoph StehlingWalter Heindel
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Mar 11, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Zhiqiang LiJames G Pipe
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Dec 3, 2010·Journal of Neurophysiology·Kenji W KoyanoYasushi Miyashita

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