Brain inflammation, neurodegeneration and seizure development following picornavirus infection markedly differ among virus and mouse strains and substrains

Experimental Neurology
Sonja BröerW Löscher

Abstract

Infections, particularly those caused by viruses, are among the main causes of acquired epilepsy, but the mechanisms causing epileptogenesis are only poorly understood. As a consequence, no treatment exists for preventing epilepsy in patients at risk. Animal models are useful to study epileptogenesis after virus-induced encephalitis and how to interfere with this process, but most viruses that cause encephalitis in rodents are associated with high mortality, so that the processes leading to epilepsy cannot be investigated. Recently, intracerebral infection with Theiler's murine encephalomyelitis virus (TMEV) in C57BL/6 (B6) mice was reported to induce early seizures and epilepsy and it was proposed that the TMEV mouse model represents the first virus infection-driven animal model of epilepsy. In the present study, we characterized this model in two B6 substrains and seizure-resistant SJL/J mice by using three TMEV (sub)strains (BeAn-1, BeAn-2, DA). The idea behind this approach was to study what is and what is not necessary for development of acute and late seizures after brain infection in mice. Receiver operating characteristic (ROC) curve analysis was used to determine which virus-induced brain alterations are associated wit...Continue Reading

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Citations

Jun 28, 2016·Scientific Reports·Charles L HoweEric J Buenz
Jan 10, 2020·Brain Pathology·Andreas JunkerChristine Stadelmann
Jul 7, 2018·Molecular Neurobiology·Luca BartoliniWilliam D Gaillard
Jan 24, 2019·International Journal of Molecular Sciences·Ingo GerhauserAndreas Beineke
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Sep 21, 2018·International Journal of Molecular Sciences·Ekaterina NikitinaJulia Kzhyshkowska
Mar 25, 2018·Veterinary Immunology and Immunopathology·Adnan FayyadChristina Puff
Aug 28, 2021·International Journal of Molecular Sciences·Kirsten HülskötterWolfgang Baumgärtner

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