Brain intra- and extracellular sodium concentration in multiple sclerosis: a 7 T MRI study

Brain : a Journal of Neurology
Maria PetraccaM Inglese

Abstract

Intra-axonal accumulation of sodium ions is one of the key mechanisms of delayed neuro-axonal degeneration that contributes to disability accrual in multiple sclerosis. In vivo sodium magnetic resonance imaging studies have demonstrated an increase of brain total sodium concentration in patients with multiple sclerosis, especially in patients with greater disability. However, total sodium concentration is a weighted average of intra- and extra-cellular sodium concentration whose changes reflect different tissue pathophysiological processes. The in vivo, non-invasive measurement of intracellular sodium concentration is quite challenging and the few applications in patients with neurological diseases are limited to case reports and qualitative assessments. In the present study we provide first evidence of the feasibility of triple quantum filtered (23)Na magnetic resonance imaging at 7 T, and provide in vivo quantification of global and regional brain intra- and extra-cellular sodium concentration in 19 relapsing-remitting multiple sclerosis patients and 17 heathy controls. Global grey matter and white matter total sodium concentration (respectively P < 0.05 and P < 0.01), and intracellular sodium concentration (both P < 0.001) w...Continue Reading

References

Dec 1, 1965·Brain : a Journal of Neurology·O Périer, A Grégoire
Nov 1, 1993·Trends in Neurosciences·C P Taylor
Aug 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·P K StysS G Waxman
Nov 26, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·I HancuG X Shen
Dec 2, 1999·Journal of Magnetic Resonance·A BorthakurR Reddy
May 17, 2000·Journal of Magnetic Resonance Imaging : JMRI·N BansalC R Malloy
Sep 28, 2000·The New England Journal of Medicine·J H NoseworthyB G Weinshenker
Jul 24, 2002·Brain : a Journal of Neurology·David H MillerAlan J Thompson
Oct 23, 2002·Human Brain Mapping·Stephen M Smith
Mar 29, 2003·Radiology·Ronald OuwerkerkPaul A Bottomley
Jun 14, 2003·Brain : a Journal of Neurology·Michael SailerAnders Dale
Jul 2, 2003·Neurotoxicity Research·Carl Bjartmar, Bruce D Trapp
May 3, 2005·Journal of Magnetic Resonance·Costin Tanase, Fernando E Boada
Oct 12, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Robert Stobbe, Christian Beaulieu
Oct 19, 2005·Brain : a Journal of Neurology·Alexandra KutzelniggHans Lassmann
Aug 26, 2006·Brain : a Journal of Neurology·Joel A BlackStephen G Waxman
Nov 23, 2006·Nature Reviews. Neuroscience·Stephen G Waxman
Jan 16, 2007·Journal of Neurology·David A BechtoldKenneth J Smith
Jan 30, 2008·Nature Clinical Practice. Neurology·Stephen G Waxman
Feb 24, 2009·Lancet Neurology·Bruce D Trapp, Peter K Stys
Apr 3, 2009·Brain : a Journal of Neurology·Josa M FrischerHans Lassmann
Dec 17, 2009·Journal of Magnetic Resonance·Christian MatthiesPeter Bachert
Jan 30, 2010·Brain : a Journal of Neurology·M IngleseG Johnson
Feb 12, 2010·Brain : a Journal of Neurology·Joel A BlackStephen G Waxman
Mar 11, 2010·Multiple Sclerosis : Clinical and Laboratory Research·Emma C TallantyreNikos Evangelou
Oct 27, 2010·Annals of Neurology·Roberta MagliozziRichard Reynolds
Mar 30, 2011·Annals of Neurology·Graham R CampbellDon J Mahad
Sep 2, 2011·Human Brain Mapping·Marco BattagliniNicola De Stefano
Oct 1, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Adrian TsangChristian Beaulieu
Jun 21, 2012·NMR in Biomedicine·Lazar FleysherMatilde Inglese
Jul 26, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Daniel P FiegeN Jon Shah
Nov 13, 2012·PloS One·Francesca RossiNicola De Stefano

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Citations

Oct 5, 2016·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Daniel Ontaneda, Robert J Fox
Jul 1, 2017·Multiple Sclerosis : Clinical and Laboratory Research·Raj Kapoor
Mar 22, 2018·Current Opinion in Neurology·Matilde Inglese, Maria Petracca
Aug 5, 2017·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Kedar R Mahajan, Daniel Ontaneda
Oct 25, 2017·Multiple Sclerosis : Clinical and Laboratory Research·Maxime DonadieuJean-Philippe Ranjeva
May 23, 2019·Neurodegenerative Disease Management·Dejan JakimovskiRobert Zivadinov
Jan 26, 2018·Expert Review of Neurotherapeutics·Matilde IngleseMaria Petracca
May 19, 2019·Journal of Magnetic Resonance Imaging : JMRI·Ruomin HuLothar R Schad
Jun 2, 2020·Journal of Magnetic Resonance Imaging : JMRI·Bhavana S SolankyClaudia A M Gandini Wheeler-Kingshott
Nov 25, 2016·JCI Insight·Benjamin SchattlingManuel A Friese
Sep 15, 2017·Annals of Clinical and Translational Neurology·Francesco GrussuClaudia A M Gandini Wheeler-Kingshott
Dec 13, 2019·Translational Neurodegeneration·Jeroen Van SchependomMiguel D'haeseleer
Feb 19, 2017·The Journal of Physiology·Meneka KanagaratnamMark D Baker
Jul 6, 2019·Therapeutic Advances in Neurological Disorders·Rosa CorteseAhmed T Toosy
May 2, 2019·Therapeutic Advances in Neurological Disorders·Marcello MocciaOlga Ciccarelli
Jun 29, 2018·Current Opinion in Neurology·Massimo FilippiMaria A Rocca
Oct 19, 2019·Magma·Ryszard Stefan GomolkaCristina Rossi
Mar 18, 2017·Journal of Magnetic Resonance·Victor D SchepkinThomas F Budinger
Apr 4, 2021·Brain Sciences·Maria PetraccaVincenzo Brescia Morra
Apr 28, 2021·Brain : a Journal of Neurology·Sara ColloroneAhmed T Toosy
May 1, 2021·Brain Communications·Teresa GerhalterGuillaume Madelin
Aug 3, 2021·Frontiers in Neurology·Robert StobbeChristian Beaulieu
Jul 15, 2021·Journal of Magnetic Resonance Imaging : JMRI·Angelika B MenneckeArnd Doerfler
Sep 13, 2021·Investigative Radiology·Tanja PlattDaniel Paech
Jun 14, 2021·Investigative Radiology·Benjamin V IneichenDaniel S Reich
Dec 3, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Alexa HaegerFawzi Boumezbeur
Dec 18, 2021·Journal of Magnetic Resonance Imaging : JMRI·Qingping ChenWieland A Worthoff

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