Brain levels of high-energy phosphate metabolites and executive function in geriatric depression

International Journal of Geriatric Psychiatry
David G HarperBrent P Forester

Abstract

Depression in late life has been associated with difficulties in cognitive processing, particularly in the domains of executive function, processing speed and memory, and increases the risk of developing dementia suggesting a neurodegenerative phenotype. Mitochondrial dysfunction is frequently an early event in neurodegenerative illnesses and may be operative in patients with late life depression. Phosphorus magnetic resonance spectroscopy (31P MRS) allows for the quantification of bioenergetic molecules produced by mitochondria. Ten patients with late life depression and eight normal elderly controls were studied with Stroop color and interference tests, which are widely used measures of processing speed and executive function, respectively, followed by (31P) MRS 3-dimensional chemical-shift imaging measuring levels of adenosine triphosphate, phosphocreatine, inorganic phosphate, and pH over the whole brain. In all subjects, gray matter phosphocreatine was positively associated with Stroop interference. Levels of white matter adenosine triphosphate were associated with Stroop interference in subjects with late life depression but not normal elderly. There was also a complementary association between white matter inorganic phos...Continue Reading

Associated Clinical Trials

Oct 28, 2005·Brent Forester, Brent Forester

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Citations

Nov 4, 2016·BMC Medicine·Howard J AizensteinOren Tene
Apr 19, 2017·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Łukasz ZadkaMarcin Olajossy
Dec 5, 2017·International Review of Psychiatry·Liana K MathiasBrent P Forester
Jul 10, 2018·International Journal of Geriatric Psychiatry·Gregory J TranahUNKNOWN Health, Aging and Body Composition Study
Aug 28, 2019·Biomolecules·Brent M KiousPerry F Renshaw

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