Brain lipid peroxidation and antioxidant levels in fetal lambs 72 hours after asphyxia by partial umbilical cord occlusion

American Journal of Obstetrics and Gynecology
T IkedaS D Park

Abstract

The purpose of this study was to explain the role of oxidative stress in the pathogenesis of brain damage caused by intrauterine fetal asphyxia. Six chronically instrumented near-term fetal lambs were subjected to asphyxia by partial umbilical cord occlusion for approximately 60 minutes until fetal arterial pH diminished to less than 6.9 and base excess to less than -20 mEq. Another six fetuses surgically prepared but not occluded were used as control. Fetuses were killed after 72 hours and eight different brain regions (frontal and parietal gray matter, frontal and parietal white matter, basal ganglia, thalamus, hippocampus, and cerebellum) were dissected and assayed for thiobarbituric acid reactive substances, glutathione, and superoxide dismutase. Thiobarbituric acid reactive substance levels in asphyxiated animals were elevated in frontal and parietal white matter, basal ganglia, and thalamus compared with those in controls. The concentrations of superoxide dismutase in the asphyxiated group were also higher in frontal and parietal white matter, basal ganglia, and cerebellum compared with those in the control group. Between the two groups, however, glutathione concentrations did not differ significantly. These results sugge...Continue Reading

Citations

Mar 9, 2012·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Stephen A BackA Roger Hohimer
Jan 19, 2013·Journal of the South African Veterinary Association·Andreza A SilvaRoberto C Gonçalves
May 11, 2004·Seminars in Pediatric Neurology·Jerome Y Yager
Aug 15, 2019·Journal of Neurophysiology·Clarissa F CavarsanKatharina A Quinlan

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