PMID: 6162168Jan 1, 1980Paper

Brain locations controlling the behavioral effects of chronic amphetamine intoxication

Psychopharmacology
R HitzemannH Loh

Abstract

Rats were administered D-amphetamine repeatedly for 4 days. After day 1 of treatment, the amphetamine-induced increases in ambulation, rearing, and stereotyped activity were augmented. However, after 4 days treatment, the rearing and ambulatory responses became attenuated while the stereotyped activities remained augmented. Micro-injection studies revealed that both the augmentation and attenuation of nonstereotyped ambulation were generated from the nucleus accumbens. The augmentation of stereotyped behaviors was generated from the caudate nucleus. Chronically treated animals who were administered 0.7 but not 1.0 mg/kg apomorphine showed augmented behavioral response. Chronic amphetamine treatment significantly decreased (3H) spiroperidol binding in both the nucleus accumbens and caudate nucleus. However, no effect on the DA-stimulated adenyl cyclase activity was observed in either brain region. It is concluded that repeated D-amphetamine administration selectively augments and attenuates D-amphetamine-induced behaviors and that these selective effects are mediated by different dopamine systems.

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Citations

Jan 1, 1985·Psychopharmacology·S K WooH H Loh
Jun 10, 1981·European Journal of Pharmacology·S Kaneno, Y Shimazono
Oct 1, 1982·Neuropharmacology·R HitzemannH Loh
Aug 1, 1988·Pharmacology, Biochemistry, and Behavior·I WeinerJ Feldon
Mar 1, 1996·Pharmacology, Biochemistry, and Behavior·G I ElmerR B Rothman
Jan 1, 1984·Neuroscience and Biobehavioral Reviews·G V Rebec, T R Bashore
Jun 23, 2001·Pharmacology, Biochemistry, and Behavior·S M Melnick, D L Dow-Edwards
Dec 24, 1997·Brain Research. Brain Research Reviews·R C Pierce, P W Kalivas
Nov 28, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Cilene R R AlvesM Teresa A Silva
Jul 21, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Neil M Richtand
Mar 31, 2011·Behavioural Pharmacology·Anthony Sean Rauhut, Victoria Bialecki
Jun 28, 1992·Annals of the New York Academy of Sciences·D J Henry, F J White
Jun 8, 2001·Reviews in the Neurosciences·R C Pierce, A A Bari
Sep 23, 1985·Brain Research·C J SchmidtJ W Gibb
Apr 5, 1991·Brain Research·J D SteketeeP W Kalivas
Dec 18, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·François LaplanteRon M Sullivan
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Apr 18, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Neil M RichtandS Paul Berger
Jun 28, 1992·Annals of the New York Academy of Sciences·P W KalivasP Duffy

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