Brain magnetic resonance imaging abnormalities after the Norwood procedure using regional cerebral perfusion

The Journal of Thoracic and Cardiovascular Surgery
Catherine L DentC Dean Kurth

Abstract

Neurologic deficits are common after the Norwood procedure for hypoplastic left heart syndrome. Because of the association of deep hypothermic circulatory arrest with adverse neurologic outcome, regional low-flow cerebral perfusion has been used to limit the period of intraoperative brain ischemia. To evaluate the impact of this technique on brain ischemia, we performed serial brain magnetic resonance imaging in a cohort of infants before and after the Norwood operation using regional cerebral perfusion. Twenty-two term neonates with hypoplastic left heart syndrome were studied with brain magnetic resonance imaging before and at a median of 9.5 days after the Norwood operation. Results were compared with preoperative, intraoperative, and postoperative risk factors to identify predictors of neurologic injury. Preoperative magnetic resonance imaging (n = 22) demonstrated ischemic lesions in 23% of patients. Postoperative magnetic resonance imaging (n = 15) demonstrated new or worsened ischemic lesions in 73% of patients, with periventricular leukomalacia and focal ischemic lesions occurring most commonly. Prolonged low postoperative cerebral oximetry (<45% for >180 minutes) was associated with the development of new or worsened i...Continue Reading

References

Mar 1, 1995·The Journal of Pediatrics·B T RogersD R Pieroni
Aug 1, 1993·The Journal of Thoracic and Cardiovascular Surgery·Richard A JonasJane W Newburger
Dec 31, 1997·The Journal of Thoracic and Cardiovascular Surgery·E H AustinK M Corlett
Jul 1, 1998·The Annals of Thoracic Surgery·P R Hickey
Jan 29, 2000·The Journal of Thoracic and Cardiovascular Surgery·Frank A PigulaR D Siewers
Aug 23, 2000·Circulation·Gil WernovskyJane W Newburger
Jul 24, 2001·The Annals of Thoracic Surgery·C Dean KurthSusan C Nicolson
Aug 2, 2001·The Journal of Thoracic and Cardiovascular Surgery·T SakamotoRichard A Jonas
Sep 25, 2001·Circulation·Joseph M ForbessRichard A Jonas
Mar 14, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C Dean KurthJohn McCann
Dec 11, 2003·The Journal of Thoracic and Cardiovascular Surgery·David C BellingerJane W Newburger
Mar 31, 2004·The Journal of Thoracic and Cardiovascular Surgery·Richard J MyungWilliam M DeCampli
Dec 2, 2004·The Journal of Thoracic and Cardiovascular Surgery·Daniel J LichtJohn A Detre
Dec 14, 2004·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·J R KaltmanJack Rychik

Citations

Aug 25, 2009·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Jean A BallwegJ William Gaynor
Nov 5, 2009·Cardiology in the Young·Matthew C ScanlonDavid S Cooper
May 11, 2011·Cardiology in the Young·H GlassP S McQuillen
Feb 15, 2013·Pediatric Research·Viyeka SethiP S McQuillen
Feb 3, 2007·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·P S McQuillenS P Miller
Nov 30, 2011·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Terri Marin, James Moore
Apr 7, 2011·Current Opinion in Pediatrics·Joshua D Koch, Steven G Kernie
Nov 26, 2009·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Maria T ZuluagaP S McQuillen
Jul 8, 2010·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·William B Waldrop, Jose A Pineda
Jan 4, 2012·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Nancy S GhanayemGeorge M Hoffman
Sep 13, 2007·Archives of Disease in Childhood. Fetal and Neonatal Edition·S P Miller, P S McQuillen
Dec 21, 2010·Surgical Neurology International·Erin A BoothMichael Wider
Jan 10, 2014·Annals of Cardiac Anaesthesia·Alexander J C Mittnacht, Cesar Rodriguez-Diaz
Jan 6, 2015·Saudi Journal of Anaesthesia·Aymen N NaguibTimothy M Hoffman
Aug 26, 2014·The Annals of Thoracic Surgery·Mark A FogelDaniel J Licht
Jun 12, 2010·Journal of Perinatology : Official Journal of the California Perinatal Association·S McNeillB Engelhardt
Apr 15, 2014·Seminars in Thoracic and Cardiovascular Surgery. Pediatric Cardiac Surgery Annual·Francisco A Guzmán-Pruneda, Charles D Fraser
May 4, 2013·Pediatric Clinics of North America·Ronald A Bronicki, Paul A Checchia
Jan 5, 2013·Annales Françaises D'anesthèsie Et De Rèanimation·O RauxC Dadure
Jan 16, 2013·The Journal of Thoracic and Cardiovascular Surgery·George M HoffmanNancy S Ghanayem
Nov 7, 2015·The Annals of Thoracic Surgery·George M HoffmanKathleen A Mussatto
Aug 4, 2012·The Annals of Thoracic Surgery·Renee N KreegerC Dean Kurth
Jun 28, 2011·The Annals of Thoracic Surgery·Mohamed LyAlain Serraf
Aug 31, 2010·Progress in Pediatric Cardiology·P S McQuillenDaniel J Licht
May 4, 2010·The Journal of Thoracic and Cardiovascular Surgery·A J BlockS P Miller
Mar 24, 2010·Seminars in Thoracic and Cardiovascular Surgery. Pediatric Cardiac Surgery Annual·Jennifer C HirschJames G Gurney
Nov 17, 2009·The Journal of Thoracic and Cardiovascular Surgery·Dean B AndropoulosCharles D Fraser
Mar 28, 2009·The Annals of Thoracic Surgery·Anita SzwastJack Rychik
Mar 31, 2009·The Journal of Thoracic and Cardiovascular Surgery·Richard G OhyeMichigan Congenital Heart Outcomes Research and Discovery Investigators
Jan 22, 2009·The Journal of Thoracic and Cardiovascular Surgery·Jennifer C HirschJames G Gurney
Apr 9, 2008·Seminars in Thoracic and Cardiovascular Surgery. Pediatric Cardiac Surgery Annual·David P NelsonCharles D Fraser
Apr 9, 2008·Seminars in Thoracic and Cardiovascular Surgery. Pediatric Cardiac Surgery Annual·Charles D Fraser, Dean B Andropoulos
Nov 7, 2007·Seminars in Thoracic and Cardiovascular Surgery·Troy E DominguezJ William Gaynor
Feb 5, 2008·The Journal of Thoracic and Cardiovascular Surgery·Jane W NewburgerDavid Wypij
Jan 9, 2008·The Journal of Thoracic and Cardiovascular Surgery·Jia LiGlen S Van Arsdell
Nov 28, 2006·The Annals of Thoracic Surgery·Karen J ViscontiFrank A Pigula
Mar 19, 2011·Paediatric Anaesthesia·Nicholette Kasman, Ken Brady

Related Concepts

Related Feeds

Basal Ganglia Cerebrovascular Disease

Basal ganglia cerebrovascular disease is a condition where the blood vessels in the basal ganglia are damaged or malfunction. Discover the latest research on basal ganglia cerebrovascular disease here.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.