Brain magnetic resonance imaging and magnetic resonance spectroscopy findings of children with kernicterus

Polish journal of radiology
Sahabettin SarıHuseyin Caksen

Abstract

The term kernicterus, or bilirubin encephalopathy, is used to describe pathological bilirubin staining of the basal ganglia, brain stem, and cerebellum, and is associated with hyperbilirubinemia. Kernicterus generally occurs in untreated hyperbilirubinemia or cases where treatment is delayed. Magnetic resonance imaging (MRI)-based studies have shown characteristic findings in kernicterus. The objective of our study was to describe the role of (1)H magnetic resonance spectroscopy (MRS) in demonstrating these metabolic changes and to review conventional MRI findings of kernicterus. Forty-eight pediatric cases with kernicterus were included in this study. MRI and MRS examinations were performed on variable dates (10-29 days after birth). NAA, Cr, Cho, NAA/Cr, NAA/Cho, and Cho/Cr values were evaluated visually and by computer analysis. There was no statistically significant difference between the NAA and Cho levels in the acute kernicterus patients and the control group (healthy patients), whereas both were significantly elevated in the chronic kernicterus patients. Both the mean NAA/Cr and Cho/Cr ratio values were significantly higher in the acute and chronic cases compared to the control group. The NAA/Cho ratio value was statist...Continue Reading

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Citations

Mar 29, 2020·Journal of Computer Assisted Tomography·Ahmed Abdel Khalek Abdel RazekNoha El Tantawi
Feb 23, 2019·Indian Journal of Pediatrics·Pooja AbbeyPriyanka Naranje
Aug 20, 2019·Journal of Veterinary Emergency and Critical Care·Geoff G HeffnerBenjamin Nolan
Dec 17, 2020·Seminars in Perinatology·Iman Iskander, Rasha Gamaleldin
Jan 23, 2021·AJNR. American Journal of Neuroradiology·V SchmidbauerG Kasprian

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