Brain Magnetic Susceptibility Changes in Patients with Natalizumab-Associated Progressive Multifocal Leukoencephalopathy.

AJNR. American Journal of Neuroradiology
J HodelX Leclerc

Abstract

We investigated the brain magnetic susceptibility changes induced by natalizumab-associated progressive multifocal leukoencephalopathy. We retrospectively included 12 patients with natalizumab-progressive multifocal leukoencephalopathy, 5 with progressive multifocal leukoencephalopathy from other causes, and 55 patients with MS without progressive multifocal leukoencephalopathy for comparison. MR imaging examinations included T2* or SWI sequences in patients with progressive multifocal leukoencephalopathy (86 examinations) and SWI in all patients with MS without progressive multifocal leukoencephalopathy. Signal abnormalities on T2* and SWI were defined as low signal intensity within the cortex and/or U-fibers and the basal ganglia. We observed T2* or SWI signal abnormalities at the chronic stage in all patients with progressive multifocal leukoencephalopathy, whereas no area of low SWI signal intensity was detected in patients without progressive multifocal leukoencephalopathy. Among the 8 patients with asymptomatic natalizumab-progressive multifocal leukoencephalopathy, susceptibility changes were observed in 6 (75%). The basal ganglia adjacent to progressive multifocal leukoencephalopathy lesions systematically appeared hypo...Continue Reading

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Citations

Dec 5, 2015·AJNR. American Journal of Neuroradiology·P LabaugeN Menjot de Champfleur
Dec 5, 2015·AJNR. American Journal of Neuroradiology·J HodelX Leclerc
Oct 1, 2016·Current Infectious Disease Reports·Deanna Saylor, Arun Venkatesan
Jun 9, 2017·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Yuki AritaMasahiro Jinzaki
Sep 16, 2017·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Eric M L Williamson, Joseph R Berger
Apr 20, 2018·Neurology·Joseph R BergerMartin Merschhemke
Oct 19, 2017·Journal of Neuropathology and Experimental Neurology·Minkyeong KimJae-Hyeok Lee
Mar 14, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·S Richard DunhamDavid B Clifford

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