Brain maturation-related spike localization in Panayiotopoulos syndrome: magnetoencephalographic study

Pediatric Neurology
Naka SaitoMakoto Uchiyama

Abstract

Focal spike activities in Panayiotopoulos syndrome involve all brain regions in electroencephalography, and commonly reveal multiple foci, often through occipital predominance. To investigate correlations between developmental brain maturation and spike origin in Panayiotopoulos syndrome, we evaluated age-related or duration-related magnetoencephalographic spike localization in 25 patients with Panayiotopoulos syndrome. Regarding age at examination, patients with frontal spikes were significantly older than patients with spikes on rolandic, parieto-occipital, or calcarine sulci. Occipital spikes were classified into two subgroups, located at the calcarine sulcus and parieto-occipital sulcus. Both calcarine and parieto-occipital localizations were seen in patients around the same age. Follow-up magnetoencephalography was performed on three patients, and demonstrated shifting localization or disappearance of magnetoencephalographic spikes. These results suggest that the location of spike discharges is not directly related to seizure symptoms, but instead indicates maturation-related cortical hyperexcitability in patients with Panayiotopoulos syndrome.

References

Nov 1, 1988·Journal of Neurology, Neurosurgery, and Psychiatry·C P Panayiotopoulos
Jul 1, 1994·Clinical EEG (electroencephalography)·T KonishiS Yagi
Jul 1, 1993·Epilepsia·K WatanabeA Matsumoto
Sep 21, 2000·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·F VigevanoS Ricci
Mar 27, 2001·Lancet·C D Ferrie, R A Grünewald
Nov 13, 2001·Pediatric Neurology·H OguniM Osawa
Nov 1, 1954·A.M.A. American Journal of Diseases of Children·E L GIBBSF A GIBBS
Jan 1, 2005·Brain & Development·Harumi YoshinagaEiji Oka
Jul 20, 2005·Epilepsia·Osamu KanazawaTakanori Kamimura
Feb 18, 2006·Developmental Medicine and Child Neurology·Colin FerrieHarami Yoshinaga
May 3, 2006·Epilepsia·Harumi YoshinagaYoko Ohtsuka
Mar 14, 2007·Pediatric Neurology·Naka SaitohTakanori Kamimura

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Citations

Aug 23, 2008·Brain : a Journal of Neurology·Chrysostomos P PanayiotopoulosMichael Koutroumanidis
Oct 3, 2012·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Iván Sánchez Fernández, Tobias Loddenkemper
Mar 7, 2014·Brain : a Journal of Neurology·Carolina CiumasPhilippe Ryvlin
Mar 2, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Vasileios KokkinosChrysostomos P Panayiotopoulos
Oct 27, 2012·Epilepsy & Behavior : E&B·Brian MoseleyChrysostomos P Panayiotopoulos

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