Brain Metastases from Lung Cancer: Is MET an Actionable Target?

Cancers
Giulia Maria StellaSilvia Benvenuti

Abstract

The process of metastatic dissemination begins when malignant cells start to migrate and leave the primary mass. It is now known that neoplastic progression is associated with a combination of genetic and epigenetic events. Cancer is a genetic disease and this pathogenic concept is the basis for a new classification of tumours, based precisely on the presence of definite genetic lesions to which the clones are addicted. Regarding the scatter factor receptors MET and Recepteur d'Origin Nantais (RON), it is recognised that MET is an oncogene necessary for a narrow subset of tumours (MET-addicted) while it works as an adjuvant metastogene for many others. This notion highlights that the anti-MET therapy can be effective as the first line of intervention in only a few MET-addicted cases, while it is certainly more relevant to block MET in cases of advanced neoplasia that exploit the activation of the invasive growth program to promote dissemination in other body parts. Few data are instead related to the role played by RON, a receptor homologous to MET. We have already demonstrated an implication of MET and RON genes in brain metastases from lung cancer. On this basis, the aim of this work is to recapitulate and dissect the molecul...Continue Reading

References

Mar 1, 1997·International Journal of Radiation Oncology, Biology, Physics·L GasparR Byhardt
Mar 31, 1999·International Journal of Radiation Oncology, Biology, Physics·F J LagerwaardP I Schmitz
Apr 27, 2001·Seminars in Cancer Biology·P M Comoglio, C Boccaccio
Aug 22, 2002·Nature Reviews. Cancer·Jean Paul Thiery
May 10, 2003·Science·Alberto BardelliVictor E Velculescu
Jul 21, 2004·Cancer Cell·Monica Kong-BeltranDineli Wickramasinghe
Dec 8, 2004·Current Opinion in Structural Biology·Ermanno GherardiE Yvonne Jones
Feb 10, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Janakiraman Subramanian, Ramaswamy Govindan
Dec 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·James BeanWilliam Pao
Dec 24, 2008·Nature Reviews. Cancer·Jianming ZhangNathanael S Gray
Oct 16, 2010·Human Mutation·Giulia M StellaPaolo M Comoglio
Nov 26, 2010·Nature Reviews. Molecular Cell Biology·Livio TrusolinoPaolo M Comoglio
Apr 6, 2011·Journal of the National Cancer Institute·Francesca De BaccoCarla Boccaccio
Jul 18, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jea-Hyun BaekThomas Hieronymus
Aug 30, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·William M Pardridge
Sep 11, 2012·Nature·UNKNOWN Cancer Genome Atlas Research Network
Feb 6, 2013·Laboratory Investigation; a Journal of Technical Methods and Pathology·Heekyoung YangDo-Hyun Nam
Jun 26, 2013·Nature Reviews. Cancer·Hang-Ping YaoMing-Hai Wang
Jun 26, 2014·Perspectives in Medicinal Chemistry·John L Mikitsh, Ann-Marie Chacko
Jul 24, 2014·Cancers·Hisato KawakamiKazuto Nishio
Aug 1, 2014·Nature·UNKNOWN Cancer Genome Atlas Research Network
Feb 15, 2015·Seminars in Cell & Developmental Biology·Yonatan SerlinAlon Friedman
Aug 21, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·William D TravisUNKNOWN WHO Panel
Aug 28, 2015·Expert Review of Respiratory Medicine·Anna TruiniGiulio Rossi
Sep 26, 2015·Cellular and Molecular Life Sciences : CMLS·Mohammed M A AlmutairiHonglian Shi
Jan 6, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mark M AwadLynette M Sholl
Feb 6, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Joanna H TongKa F To
Mar 29, 2016·Cancer Metastasis Reviews·Helmut H Popper
Jun 28, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Alexa B SchrockSai-Hong Ignatius Ou
Oct 4, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Samuel J KlempnerSai-Hong Ignatius Ou
Dec 3, 2016·Journal of Neurosurgery·Shelly X BianEric L Chang
Dec 28, 2016·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Thanyanan ReungwetwattanaSai-Hong Ignatius Ou
Jan 7, 2017·Cold Spring Harbor Symposia on Quantitative Biology·Najme Faham, Alana L Welm
May 16, 2017·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Geun Dong LeeHyeong Ryul Kim
Jul 7, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Thomas Tuxen PoulsenMichael Kragh

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Citations

May 28, 2021·Indian Journal of Nuclear Medicine : IJNM : the Official Journal of the Society of Nuclear Medicine, India·Vikrant KumarArun Gandhi

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Methods Mentioned

BETA
biopsies
biopsy
surgical resection

Clinical Trials Mentioned

NCT02143466

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