PMID: 3759534Oct 1, 1986Paper

Brain metastases from malignant melanoma: conventional vs. high-dose-per-fraction radiotherapy

International Journal of Radiation Oncology, Biology, Physics
J C Ziegler, J S Cooper

Abstract

This report examines the records of 72 patients who received various regimens of radiotherapy for cerebral metastases from malignant melanoma at NYU Medical Center. Treatment consisted of whole-brain irradiation, either with dose fractions of 300 cGy (conventional fractionation, CF) or 500-600 cGy (high-dose-per-fraction, HDF) to a total of 3000 cGy. Two-thirds of the patients responded to radiotherapy as measured by improvement of at least one functional level. No difference in response could be attributed to dose schedules, either overall or in the subgroups of patients who had solitary or multiple brain metastases. Median survival was not significantly affected by fractionation schedule; however, patients who had solitary metastases survived longer, probably because of the nature of their disease. Treatment related toxicity was more frequent in the HDF group. The subgroup of patients who had their only clinically demonstrable lesion grossly excised prior to treatment survived more than twice as long as other patients. We conclude that radiotherapy is effective in palliating symptoms for these patients. Our data does not support the use of HDF techniques in the treatment of patients with brain metastases from malignant melanoma.

Citations

Nov 28, 2002·Head & Neck·Timothy D AndersonDavid I Rosenthal
Nov 1, 1992·Seminars in Surgical Oncology·F J LejeuneH Badr-el-Din
Nov 11, 2011·Current Oncology Reports·Eugene Koay, Erik P Sulman
Feb 1, 1996·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·O P IsokangasS Pyrhönen
Feb 1, 1996·Clinical Neurology and Neurosurgery·M SalvatiF M Gagliardi
Dec 1, 1996·The Surgical Clinics of North America·F B Geara, K K Ang
Feb 13, 2001·International Journal of Radiation Oncology, Biology, Physics·J EllerhorstI McCutcheon
Apr 17, 2002·International Journal of Radiation Oncology, Biology, Physics·Cheng YuZbigniew Petrovich
Nov 7, 1998·International Journal of Radiation Oncology, Biology, Physics·Y MoriL D Lunsford
Jul 18, 1991·The New England Journal of Medicine·H K Koh
Oct 31, 2002·Seminars in Oncology·Emma CattellMark R Middleton
Jul 1, 1989·Mayo Clinic Proceedings·E T Creagan
Mar 30, 1994·International Journal of Radiation Oncology, Biology, Physics·R F BarthE K Rofstad
Mar 1, 1991·International Journal of Radiation Oncology, Biology, Physics·W T SauseJ Lipsett
Oct 1, 1988·International Journal of Radiation Oncology, Biology, Physics·W R RateA T Turrisi
Sep 8, 2009·International Journal of Radiation Oncology, Biology, Physics·Dirk RadesSteven E Schild
Jan 8, 2000·Dermatologic Clinics·J M Pitts, M E Maloney
Jul 5, 2006·Neurosurgical Focus·J P RockUNKNOWN Guidelines and Outcomes Committee of the American Association of Neurological Surgeons
Nov 1, 1993·Journal of Neurosurgery·S SomazaJ C Flickinger
Jan 12, 2017·Acta Oncologica·Ragnar HultbornPer Albertsson
Mar 31, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K M FifeJ F Thompson
Mar 1, 1992·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·G StevensA Coates
Oct 14, 2005·Expert Review of Anticancer Therapy·Robert R McWilliamsJan C Buckner
Dec 10, 2003·Mayo Clinic Proceedings·Robert R McWilliamsSvetomir N Markovic
Jan 1, 1996·Acta Oncologica·R G Parker
Jun 21, 2003·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·David R ProulxDonald E Thrall
May 13, 2008·Expert Review of Anticancer Therapy·Robert R McWilliamsPaul D Brown
May 1, 1988·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·I M Mendez, R F Del Maestro
Jul 4, 2008·Cancer Control : Journal of the Moffitt Cancer Center·James M McLoughlinLawrence B Berk

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.