Brain metastases in metastatic breast cancer patients receiving trastuzumab-based therapies.

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
Javier Puente VázquezEduardo Díaz-Rubio

Abstract

CNS metastases mean a great challenge. It has been suggested that the brain metastases incidence could be high in metastasic breast cancer patients receiving trastuzumab based-therapies. We performed a descriptive analysis of our experience in this setting. 86 patients met the criteria (From Oct/99 to Oct/03). CNS progression occurred in 17 patients (19.5%). Mean age of CNS progression disease patients was 45.4 years while mean age for all the patients was 50.5 years. Response rate for the entire group of patients was: OR 39.7%; CB (OR + SD) 69%. Response rate to trastuzumab based-therapy was OR 82.4% and CB 88.2 at the time of CNS progression. Median time from the start of trastuzumab therapy up to the CNS progression was 10 months. OS was 23.4 weeks. The incidence of CNS involvement is high in young metastasic breast cancer women responding to trastuzumab-based therapies. This may lead to prophylactic cranial irradiation strategies or to the early detection in asymptomatic patients to improve surgery or radiosurgery results in these patients.

References

Jan 1, 1992·Cancer Chemotherapy and Pharmacology·M G DonelliM D'Incalci
Feb 1, 1981·Cancer·N A SamaanR Martin
Mar 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·R H BoboE H Oldfield
Mar 31, 1999·International Journal of Radiation Oncology, Biology, Physics·F J LagerwaardP I Schmitz
Apr 14, 1999·CA: a Cancer Journal for Clinicians·S H LandisP A Wingo
Aug 13, 1999·CA: a Cancer Journal for Clinicians·C Mettlin
Jun 1, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B C Pestalozzi, S Brignoli
May 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A D SeidmanC A Hudis
Feb 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles L VogelMichael Press
Mar 20, 2002·Clinical Breast Cancer·L R Laufman, K F Forsthoefel
Jul 17, 2003·Clinical Breast Cancer·Elyse E LowerDouglas K Hawley
Jan 30, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E ShmueliM Inbar
Jul 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jill S Barnholtz-SloanRaymond E Sawaya
Mar 19, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David G KirschJay S Loeffler

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Citations

Dec 3, 2011·Current Oncology Reports·Joseph A Bovi, Julia White
Jul 24, 2014·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·J ThariatF Mornex
Jun 26, 2008·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Gloria RoldánElizabeth Yan
Oct 29, 2008·International Journal of Radiation Oncology, Biology, Physics·Fleur HuangDavid Roberge
May 12, 2016·Breast Cancer Research and Treatment·William JacotFlorence Dalenc
Nov 3, 2006·Expert Review of Neurotherapeutics·Jan Drappatz, Patrick Y Wen
Apr 20, 2012·The Cochrane Database of Systematic Reviews·Lorenzo MojaRoberto D'Amico

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