Brain metastases in metastatic cancer: a review of recent advances in systemic therapies.

Expert Review of Anticancer Therapy
Ariane Steindl, Anna S Berghoff

Abstract

Introduction: Brain metastases (BM) are a frequent complication of metastatic cancer. Due to the wider availability and application of screening procedures, an increasing fraction of patients are diagnosed at the asymptomatic stage. The introduction of immune checkpoint inhibitors and targeted therapies has revolutionized treatment in several frequently BM-causing entities like metastatic lung cancer, melanoma and breast cancer. However, registered trials of new targeted and immunotherapy mostly excluded patients with BM resulting in limited knowledge of the intracranial efficacy of new systemic agents.Areas covered: The present review highlights recent advances in systemic therapies for the treatment and prophylaxis of the three leading BM causing tumors: NSCLC, melanoma and breast cancer.Expert opinion: High intracranial efficacy was observed for several next-generation tyrosine kinase inhibitors as well as immune checkpoint inhibitors, especially in patients with asymptomatic disease. Ongoing discussions addressed the need for local therapies in patients with asymptomatic BM and the availability of systemic therapy with high intracranial efficacy. Further BM-specific studies as well as BM-specific endpoints in registered tri...Continue Reading

References

Jun 19, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G L CeresoliE Villa
Sep 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nancy U LinEric P Winer
Jan 23, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jeong-Eun KimJung-Shin Lee
Jun 27, 2009·Cancer Control : Journal of the Moffitt Cancer Center·Andrew E SloanDouglas B Einstein
Oct 24, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C MassardB Escudier
Dec 22, 2009·Nature Medicine·Yvonne KienastFrank Winkler
May 5, 2010·Journal of Neuro-oncology·Kevin C De BragancaAndrew B Lassman
Sep 11, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Paul R LockmanQuentin R Smith
Dec 14, 2011·The New England Journal of Medicine·José BaselgaUNKNOWN CLEOPATRA Study Group
Jan 12, 2012·British Journal of Cancer·A BerghoffR Bartsch
Mar 29, 2012·The Cancer Journal·Michael A Davies
Mar 30, 2012·The Lancet Oncology·Kim MargolinF Stephen Hodi
Jul 19, 2012·Cancer Chemotherapy and Pharmacology·Yosuke TogashiMichiaki Mishima
Aug 18, 2012·Breast Cancer Research : BCR·Renata DuchnowskaUNKNOWN Polish Brain Metastasis Consortium
Dec 15, 2012·CNS Drugs·Rupert BartschMatthias Preusser
Oct 3, 2013·Neuro-oncology·Anna S BerghoffMatthias Preusser
Apr 17, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Sung Hee LimMyung-Ju Ahn
Jun 4, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Sara D RobinsonKartik Konduri
Oct 8, 2014·Acta Neuropathologica·Anna Sophie BerghoffMatthias Preusser
Jan 28, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel B CostaLucio Crinò
Apr 22, 2015·The New England Journal of Medicine·Caroline RobertUNKNOWN KEYNOTE-006 investigators
Aug 26, 2015·Clinical & Experimental Metastasis·Rupert BartschMatthias Preusser
Aug 27, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Akito HataYasushi Yatabe
Sep 29, 2015·The New England Journal of Medicine·Hossein BorghaeiJulie R Brahmer
Jan 27, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Georgina V LongKeith T Flaherty
Jan 30, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Martin SchulerJames C-H Yang
Feb 10, 2016·Breast Cancer Research : BCR·Richard S FinnDennis J Slamon
Apr 3, 2016·BMC Cancer·Troels Dreier ChristensenDorte Lisbet Nielsen

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