Brain methylmercury uptake in fetal, neonate, weanling, and adult rats

Environmental Research
Mineshi SakamotoKunihiko Nakai

Abstract

Fetuses and neonates are known to be highly susceptible to methylmercury (MeHg) toxicity, but little is known about the relative uptake of MeHg from blood to the developing brain. We measured time-course changes in mercury (Hg) concentrations in the brain of fetal, neonate, weanling, and adult rats after an injection of 0.08 μg (0.4 nmol) Hg/g MeHg. In the prenatal experiment, MeHg was subcutaneously injected to pregnant dams on embryonic days 17, 18, 18.5, 19, 19.5, or 20, and Hg concentrations in tissues were measured in both mothers and fetuses on embryonic day 21 (1 day before parturition). Brain Hg levels in fetuses peaked 2 days after injection and were approximately 1.5 times higher than in mothers. In the postnatal experiment, the same MeHg dose was injected subcutaneously to male rats on postnatal days 1 (neonates), 35 (weanlings), or 56 (adults). Mercury concentrations in tissues were measured 1, 2, 3, 4, 5, or 6 days after the injection. Brain Hg levels peaked most rapidly in neonates, and were approximately 1.5 times higher than levels in weanlings or adults. Throughout the examined period, peak Hg levels in the brain and the Hg brain/blood ratio 24 h after injection were highest in fetuses, followed by the levels i...Continue Reading

References

Jan 1, 1989·Archives of Toxicology·A YasutakeM Inoue
Dec 1, 1986·Journal of Biochemistry·M Taniguchi, M Inoue
Jan 15, 1988·Biochemical Pharmacology·A NaganumaN Imura
Oct 1, 1985·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·W O BerndtM Houser
Dec 1, 1970·Archives of Environmental Health·T Norseth, T W Clarkson
Mar 1, 1993·Toxicology and Applied Pharmacology·F F FarrisJ C Smith
Apr 1, 1993·Environmental Research·M SakamotoT Fujisaki
Jan 1, 1996·Archives of Toxicology·Y KajiwaraK Hirayama
Dec 11, 1997·Neurotoxicology and Teratology·P GrandjeanP J Jørgensen
Aug 13, 1999·Toxicological Sciences : an Official Journal of the Society of Toxicology·M C Newland, P A Reile
May 11, 2001·Journal of Toxicology and Environmental Health. Part a·J F YoungR H Luecke
Dec 13, 2002·Environmental Research·Mineshi SakamotoHirokatsu Akagi
May 6, 2003·The Journal of Nutrition·Thomas W Clarkson, J J Strain
Oct 13, 2009·Ecotoxicology and Environmental Safety·Mineshi SakamotoHiroshi Satoh
Jun 29, 2010·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Christy C Bridges, Rudolfs K Zalups
Nov 21, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jyothsna Gattineni, Michel Baum
Apr 24, 2014·Journal of Exposure Science & Environmental Epidemiology·Zhu ChenXiaobin Wang
Nov 11, 2017·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Henry A Spiller

❮ Previous
Next ❯

Citations

Aug 8, 2019·PloS One·Roger PamphlettSvetlana Cherepanoff
Nov 6, 2018·Neurotoxicology·Steven R Boomhower, M Christopher Newland
Dec 7, 2019·Chemosphere·Helen Tais da Rosa-SilvaJosé Cláudio Fonseca Moreira
May 23, 2021·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Kristi J ReedGreg M Landry
Jan 7, 2022·Chemical Research in Toxicology·Jingjing PanWei Liu
Jan 7, 2022·The Journal of Toxicological Sciences·Takamitsu UnokiMasatake Fujimura

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.