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Brain microsomal oxidation of delta 8- and delta 9-tetrahydrocannabinol

Biochemical and Biophysical Research Communications

Nov 30, 1988

Kimiko WatanabeHisae Yoshimura

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Abstract

Brain microsomes of mice, rats, guinea pigs and rabbits catalyzed the oxidation of delta 8- and delta 9-tetrahydrocannabinol to their monohydroxylated metabolites. The most prominent metabolite was the 4'-hydroxylated metabolite on the pentyl side chain of the cannabinoids in all specie...read more

Mentioned in this Paper

Hydroxylation
Cannabinoid Drug Class Measurement
Cannabinoids Measurement
Metazoa
Mixed Function Oxygenases
Chinchilla Rabbits
Brain
Cytochrome P-450 Oxygenase
Cannabinoids
Mass Spectrometry
Paper Details
References
  • References13
  • Citations3
12

Brain microsomal oxidation of delta 8- and delta 9-tetrahydrocannabinol

Biochemical and Biophysical Research Communications

Nov 30, 1988

Kimiko WatanabeHisae Yoshimura

PMID: 2848522

DOI: 10.1016/s0006-291x(88)80013-5

Abstract

Brain microsomes of mice, rats, guinea pigs and rabbits catalyzed the oxidation of delta 8- and delta 9-tetrahydrocannabinol to their monohydroxylated metabolites. The most prominent metabolite was the 4'-hydroxylated metabolite on the pentyl side chain of the cannabinoids in all specie...read more

Mentioned in this Paper

Hydroxylation
Cannabinoid Drug Class Measurement
Cannabinoids Measurement
Metazoa
Mixed Function Oxygenases

Related Papers

Paper Details
References
  • References13
  • Citations3
12

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