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Brain microsomal oxidation of delta 8- and delta 9-tetrahydrocannabinol

Biochemical and Biophysical Research Communications

Nov 30, 1988

K WatanabeH Yoshimura

Abstract

Brain microsomes of mice, rats, guinea pigs and rabbits catalyzed the oxidation of delta 8- and delta 9-tetrahydrocannabinol to their monohydroxylated metabolites. The most prominent metabolite was the 4'-hydroxylated metabolite on the pentyl side chain of the cannabinoids in all specie...read more

Mentioned in this Paper

Cannabinoids
Metabolic Process, Cellular
Tetrahydrocannabinol
Cavia
Microsomes
Brain
Hepatic
Cytochrome P-450 Oxygenase
Oxidation
Mass Spectrometry
Paper Details
References
  • References13
  • Citations5
12
  • References13
  • Citations5
1

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Brain microsomal oxidation of delta 8- and delta 9-tetrahydrocannabinol

Biochemical and Biophysical Research Communications

Nov 30, 1988

K WatanabeH Yoshimura

PMID: 2848522

DOI: 10.1016/s0006-291x(88)80013-5

Abstract

Brain microsomes of mice, rats, guinea pigs and rabbits catalyzed the oxidation of delta 8- and delta 9-tetrahydrocannabinol to their monohydroxylated metabolites. The most prominent metabolite was the 4'-hydroxylated metabolite on the pentyl side chain of the cannabinoids in all specie...read more

Mentioned in this Paper

Cannabinoids
Metabolic Process, Cellular
Tetrahydrocannabinol
Cavia
Microsomes
Brain
Hepatic
Cytochrome P-450 Oxygenase
Oxidation
Mass Spectrometry

Similar Papers Found In These Feeds

Oxygenation & Hydroxylation

Oxygenation is a chemical production that introduces oxygen atom into an organic compound. Hydroxylation is a chemical process that introduces a hydroxyl group (-OH) into an organic compound. In biochemistry, hydroxylation reactions are often facilitated by enzymes called hydroxylases. Cytochrome P450 (CYP) enzymes are expressed mainly in the liver and are active in mono-oxygenation and hydroxylation of various xenobiotics, including drugs and alcohols, as well as that of endogenous compounds such as steroids, bile acids, prostaglandins, leukotrienes and biogenic amines. Here is the latest research.

Related Papers

Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology

In vitro metabolism of delta-11-tetrahydrocannabinol in the mouse, rat, guinea pig, rabbit, hamster, gerbil and cat

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D J Harvey, N K Brown
Rapid Communications in Mass Spectrometry : RCM

A method for the structural determination of cannabichromene metabolites by mass spectrometry

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Paper Details
References
  • References13
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  • References13
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1
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