Brain microstructural abnormalities revealed by diffusion tensor images in patients with treatment-resistant depression compared with major depressive disorder before treatment

European Journal of Radiology
Yan ZhouJian-rong Xu

Abstract

Treatment-resistant depression (TRD) is a therapeutic challenge for clinicians. Despite a growing interest in this area, an understanding of the pathophysiology of depression, particularly TRD, remains lacking. This study aims to detect the white matter abnormalities of whole brain fractional anisotropy (FA) in patients with TRD compared with major depressive disorder (MDD) before treatment by voxel-based analysis using diffusion tensor imaging. A total of 100 patients first diagnosed with untreated MDD underwent diffusion tensor imaging scans. 8 weeks after the first treatment, 54 patients showed response to the medication, whereas 46 did not. Finally, 20 patients were diagnosed with TRD after undergoing another treatment. A total of 20 patients with TRD and another 20 with MDD before treatment matched in gender, age, and education was enrolled in the research. For every subject, an FA map was generated and analyzed using SPM5. Subsequently, t-test was conducted to compare the FA values voxel to voxel between the two groups (p<0.001 [FDR corrected], t>7.57, voxel size>30). Voxel-based morphometric (VBM) analysis was performed using T1W images. Significant reductions in FA were found in the white matter located in the bilateral...Continue Reading

References

Dec 1, 1967·The British Journal of Social and Clinical Psychology·M Hamilton
Jun 1, 1996·Journal of Magnetic Resonance. Series B·P J Basser, C Pierpaoli
Oct 30, 2001·Psychological Medicine·T PetersenA A Nierenberg
May 2, 2002·The British Journal of Psychiatry : the Journal of Mental Science·P J ShahK P Ebmeier
Jul 12, 2002·International Journal of Geriatric Psychiatry·Ming-Hong HsiehDavid C Steffens
Apr 18, 2003·Hippocampus·Eleanor A MaguireNeil Burgess
Jan 1, 1959·The British Journal of Medical Psychology·M HAMILTON
Jan 1, 1965·Archives of General Psychiatry·W W ZUNG
Jan 28, 2004·Biological Psychiatry·Warren D TaylorJames R MacFall
May 7, 2005·Metabolism: Clinical and Experimental·Bruce S McEwen
Jan 27, 2006·International Clinical Psychopharmacology·Stuart A Montgomery
Feb 2, 2006·The British Journal of Psychiatry : the Journal of Mental Science·Dan V IosifescuMaurizio Fava
Oct 7, 2006·Journal of Psychiatric Research·Michael CollaIsabella Heuser
Apr 25, 2007·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Michael BauerUNKNOWN WFSBP Task Force on Unipolar Depressive Disorders
Jul 3, 2007·Hippocampus·Jerome J MallerPaul B Fitzgerald
May 31, 2008·Psychiatry Research·Christina P FurtadoPaul B Fitzgerald
Sep 25, 2008·PloS One·Warren D TaylorP Murali Doraiswamy
Dec 22, 2009·Expert Review of Neurotherapeutics·Tom Bschor

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Citations

May 12, 2012·The British Journal of Psychiatry : the Journal of Mental Science·James ColeCynthia H Y Fu
Apr 10, 2015·Annals of the New York Academy of Sciences·Marc S Lener, Dan V Iosifescu
Sep 23, 2014·Journal of Affective Disorders·Tobias BrachtSebastian Walther
Oct 27, 2016·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Rodney J AndersonPaul B Fitzgerald
Aug 10, 2017·Depression and Anxiety·Anca-Larisa SanduMarie-Laure Paillère Martinot
Mar 2, 2019·European Psychiatry : the Journal of the Association of European Psychiatrists·Xinyi WangQing Lu
Aug 28, 2014·Current Opinion in Pediatrics·Alexandra BailinAndrew Adesman
Mar 6, 2018·Journal of Clinical Neurology·Woo Suk TaeByung Jo Kim

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