Brain microvessel endothelin type A receptors are coupled to ceramide production

Biochemical and Biophysical Research Communications
M Pilar ColladoR Edgardo Catalán

Abstract

Treatment of brain microvessels with endothelin-1 evoked an early decrease in the sphingomyelin levels concomitantly with an increase in those of ceramides. These responses were time- and concentration-dependent. Evidence also shows that endothelin type A receptors are involved. This is the first report on the involvement of an agonist in the regulation of the ceramide signal transduction system on blood-brain barrier and shows a new pathway likely involved in the regulation of the cerebral microvascular functioning.

References

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Citations

Nov 12, 2003·Microvascular Research·M Pilar ColladoR Edgardo Catalán
Aug 8, 2014·Pharmaceutical Research·Christopher A PalmiottiLuca Cucullo
Jan 4, 2012·Journal of Pharmaceutical Sciences·Pooja Naik, Luca Cucullo
Nov 6, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Sean P Didion, Frank M Faraci
Oct 13, 2017·Journal of Neurochemistry·Rajkumar VutukuriWaltraud Pfeilschifter

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