PMID: 8943061Nov 26, 1996Paper

Brain monoamine oxidase A inhibition in cigarette smokers

Proceedings of the National Academy of Sciences of the United States of America
Joanna S FowlerA P Wolf

Abstract

Several studies have documented a strong association between smoking and depression. Because cigarette smoke has been reported to inhibit monoamine oxidase (MAO) A in vitro and in animals and because MAO A inhibitors are effective antidepressants, we tested the hypothesis that MAO A would be reduced in the brain of cigarette smokers. We compared brain MAO A in 15 nonsmokers and 16 current smokers with [11C]clorgyline and positron emission tomography (PET). Four of the nonsmokers were also treated with the antidepressant MAO inhibitor drug, tranylcypromine (10 mg/day for 3 days) after the baseline PET scan and then rescanned to assess the sensitivity of [11C]clorgyline binding to MAO inhibition. MAO A levels were quantified by using the model term lambda k3 which is a function of brain MAO A concentration. Smokers had significantly lower brain MAO A than nonsmokers in all brain regions examined (average reduction, 28%). The mean lambda k3 values for the whole brain were 0.18 +/- 0.04 and 0.13 +/- 0.03 ccbrain (mlplasma)-1 min-1 for nonsmokers and smokers, respectively; P < 0.0003). Tranyl-cypromine treatment reduced lambda k3 by an average of 58% for the different brain regions. Our results show that tobacco smoke exposure is as...Continue Reading

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References

Sep 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R A KoeppeD E Kuhl
Feb 1, 1990·British Journal of Addiction·J E HenningfieldW Pollin
Sep 26, 1990·JAMA : the Journal of the American Medical Association·A H GlassmanJ Johnson
Jan 16, 1988·Lancet·R G Pickard
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·G Di Chiara, A Imperato
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A W BachJ C Shih
Jan 1, 1986·Clinical Neuropharmacology·K D McDaniel
Dec 1, 1984·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·G Blomqvist
Mar 1, 1983·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C S PatlakJ D Fenstermacher
Nov 1, 1993·Trends in Neurosciences·C W Olanow
Feb 1, 1994·Progress in Neurobiology·M D BerryI A Paterson
Jan 1, 1993·Archives of General Psychiatry·N BreslauP Andreski
Dec 1, 1995·Biological Psychiatry·I BerlinA J Puech
Feb 22, 1996·Nature·J S FowlerR Cilento
Jan 1, 1996·British Medical Bulletin·N J Wald, A K Hackshaw
Nov 8, 1952·Journal of the American Medical Association·I J SELIKOFFG G ORNSTEIN

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Citations

Mar 9, 2011·Archives of General Psychiatry·Nelly Alia-KleinRita Z Goldstein
Aug 6, 1999·Journal of Clinical Pharmacology·J S FowlerR Hitzemann
Nov 26, 2009·Psychopharmacology·Elysia SmallAdrie W Bruijnzeel
Jan 14, 2010·Psychopharmacology·Anne-Sophie VillégierFrances M Leslie
Dec 31, 2010·Journal of Neural Transmission·Sarah E Dixon Clarke, Rona R Ramsay
Nov 3, 2005·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Joanna S FowlerGene-Jack Wang
May 8, 2013·Brain Imaging and Behavior·Daniel S AlbrechtKarmen K Yoder
Jun 15, 2005·Addictive Behaviors·Zeena HarakehRutger C M E Engels
Jun 7, 2005·Pharmacology, Biochemistry, and Behavior·Caroline CohenGuy Griebel
Jan 16, 2004·Trends in Pharmacological Sciences·Tony P George, Stephanie S O'Malley
May 4, 2004·Trends in Pharmacological Sciences·Wassilios MeissnerErwan Bezard
Jun 1, 2005·Trends in Pharmacological Sciences·Bernard Le Foll, Steven R Goldberg
Jan 3, 2001·European Journal of Pharmacology·T ArinamiE S Onaivi
Jan 1, 1997·Life Sciences·G J WangN R Pappas
Jun 6, 2000·Pharmacology, Biochemistry, and Behavior·D J Balfour, D L Ridley
Nov 14, 2002·Neurotoxicology·Maryka Quik, Jennifer M Kulak
Nov 14, 2002·Neurotoxicology·Donato A Di MonteAmy B Manning-Bog
Feb 5, 2003·Neurotoxicology·Joanna S FowlerNora D Volkow
May 24, 2003·Journal of Inorganic Biochemistry·Nadia Z ShabanMamdouh S Masoud
Oct 20, 2001·Progress in Neuro-psychopharmacology & Biological Psychiatry·M HarroJ Harro
May 22, 2003·Drug and Alcohol Dependence·Eric T MoolchanJack E Henningfield
Aug 26, 1998·Drug and Alcohol Dependence·S J Gatley, N D Volkow
Jan 15, 2002·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Renske SpijkermanDurk Fekkes
Oct 2, 2001·Nuclear Medicine and Biology·J S FowlerC D Arnett
Aug 17, 2002·Methods : a Companion to Methods in Enzymology·Joanna S FowlerYu-Shin Ding
May 13, 2009·Acta Pharmacologica Sinica·Zheng-xiong XiEliot L Gardner
Oct 28, 2005·Nature Neuroscience·John A Dani, R Adron Harris
Nov 6, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Joanna S FowlerKaren Apelskog-Torres
Jun 10, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Shakevia JohnsonXiao-Ming Ou
Mar 23, 2006·Nature Reviews. Neuroscience·Moussa B H YoudimKeith F Tipton
Jan 6, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Anne-Sophie VillégierJean-Pol Tassin

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