PMID: 15374405Jan 1, 1992Paper

Brain monoamine oxidase and aging: a review

Archives of Gerontology and Geriatrics
S G Burchinsky, S M Kuznetsova

Abstract

The present state of research on the age-related dynamics of brain monoamine oxidase (MAO) activity and its role in the development of age pathology is described. Special attention is given to the role of MAO in the pathogenesis of parkinsonism and to the mechanisms of its interaction with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a possible etiological factor of parkinsonism development in aging. The mechanisms of action of the selective MAO-B inhibitor, deprenyl, and their peculiarities in old age are analyzed. This study provides evidence pointing to a need for the use of deprenyl in geriatric practice as an effective drug for parkinsonism treatment and as a potent geroprotector.

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Citations

Jul 1, 1995·Neurobiology of Aging·G Benzi, A Moretti
Feb 7, 1998·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·E Y SözmenN I Hariri
Apr 20, 1999·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·G AlperB Ersöz
Sep 2, 1995·Lancet·C Colosimo, A Albanese
Dec 19, 2018·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Marine TournissacFrederic Calon
Jun 30, 1994·Annals of the New York Academy of Sciences·L PiantanelliA Antognini

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