Brain morphology in autism and fragile X syndrome correlates with social IQ: first report from the Canadian-Swiss-Egyptian Neurodevelopmental Study

Journal of Child Neurology
Nagwa MeguidAlan Evans

Abstract

Fragile X syndrome shares most of the behavioral phenotypic similarities with autism. How are these similarities reflected in brain morphology? A total of 10 children with autism and 7 with fragile X underwent morphological (T1) 1.5-T magnetic resonance imaging (MRI). The authors found no significant difference in total brain volumes, regional volumes, gyrification index, sulcul depth, and cerebral cortical thickness. However, children with autism showed significant decrease in the medial prefrontal bilaterally and the left anterior cingulate cortices. Regression analysis revealed positive correlation between the medial prefrontal cortical thickness and the social IQ. The authors suggest that the difference between the 2 groups in the medial prefrontal and anterior cingulate cortices thickness may entail an altered social cognitive style. Functional MRI studies directly differentiating between social indifference (autism) and social avoidance (fragile X) are needed to further characterize the spectrum of social abnormalities between these 2 groups.

References

Jan 1, 1986·American Journal of Medical Genetics·R J HagermanR Ahmad
Jan 1, 1974·Journal of the American Academy of Child Psychiatry·J D Noshpitz
Jul 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·I I Gottesman, J Shields
Mar 1, 1980·Journal of Autism and Developmental Disorders·E SchoplerK Daly
Feb 1, 1995·Nature Medicine·A L ReissM B Denckla
Aug 1, 1995·The American Journal of Psychiatry·J PivenP Palmer
Feb 1, 1995·The American Journal of Psychiatry·M ZilboviciusG Lelord
Aug 1, 1994·Journal of Autism and Developmental Disorders·M M MazzoccoR J Hagerman
Jul 1, 1994·Neurology·A L ReissL Freund
Dec 5, 1995·Proceedings of the National Academy of Sciences of the United States of America·P Rakic
Feb 16, 1996·American Journal of Medical Genetics·E W Simon, B M Finucane
May 13, 1997·Proceedings of the National Academy of Sciences of the United States of America·T A ComeryW T Greenough
Nov 14, 1998·Journal of Autism and Developmental Disorders·C Feinstein, A L Reiss
Feb 5, 1999·Journal of Autism and Developmental Disorders·D B BaileyL Mayhew
Feb 25, 1999·Journal of Intellectual Disability Research : JIDR·J Turk, K Cornish
Apr 20, 1999·American Journal of Medical Genetics·I J Weiler, W T Greenough
Aug 10, 2000·American Journal of Mental Retardation : AJMR·A S KauL Freund
Feb 22, 2002·American Journal of Medical Genetics·Deborah D HattonAnne Wheeler
Jul 24, 2002·Neurology·E H AylwardN Singh
Aug 31, 2002·NeuroImage·Ruth A CarperEric Courchesne
Sep 25, 2002·Journal of Child Neurology·Manuel F CasanovaEmil Roy
Oct 9, 2002·JAMA : the Journal of the American Medical Association·F Xavier CastellanosJudith L Rapoport
Mar 4, 2003·Nature Reviews. Neuroscience·Ralph Adolphs
Apr 2, 2003·The American Journal of Psychiatry·Irving I Gottesman, Todd D Gould
Apr 17, 2003·British Medical Bulletin·Ahmad R Hariri, Daniel R Weinberger
Aug 7, 2003·American Journal of Mental Retardation : AJMR·Jenny L DemarkJeanette J A Holden
Sep 25, 2003·European Child & Adolescent Psychiatry·Manga SabaratnamStewart Payne
Feb 10, 2004·Annals of the New York Academy of Sciences·David G Amaral
Mar 25, 2004·American Journal of Medical Genetics. Part a·Alice S M KauWalter E Kaufmann
Apr 10, 2004·American Journal of Mental Retardation : AJMR·Amy PhilofskySally J Rogers
Aug 25, 2004·American Journal of Medical Genetics. Part a·Walter E KaufmannPia Stanard
Oct 7, 2004·Psychiatry Research·Antonio Y HardanNancy J Minshew
Oct 16, 2004·Annual Review of Genomics and Human Genetics·Jeremy Veenstra-VanderweeleEdwin H Cook
Mar 15, 2005·American Journal of Mental Retardation : AJMR·Jane E RobertsDonald B Bailey
Jul 22, 2005·Annual Review of Neuroscience·Simon Baron-Cohen, Matthew K Belmonte
Sep 22, 2005·Anatomy and Embryology·Claus C Hilgetag, Helen Barbas
Jun 16, 2006·Journal of Intellectual Disability Research : JIDR·P LewisS Schroeder
Aug 15, 2006·American Journal of Medical Genetics. Part a·Dejan B BudimirovicWalter E Kaufmann
Sep 22, 2006·Nature Reviews. Neuroscience·Andreas Meyer-Lindenberg, Daniel R Weinberger

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Citations

Apr 13, 2011·Molecular Psychiatry·M A CarlessJ Blangero
May 30, 2013·Brain : a Journal of Neurology·Gregory L WallaceAlex Martin
Sep 7, 2011·Developmental Neuroscience·Dejan B Budimirovic, Walter E Kaufmann
May 17, 2013·Research in Autism Spectrum Disorders·Krissy A R Doyle-ThomasEvdokia Anagnostou
Nov 11, 2011·Brain and Cognition·Nagwa A MeguidAlan C Evans
Jun 28, 2011·NeuroImage·Dongming ZhouChristian Beaulieu
Nov 2, 2014·Frontiers in Genetics·Leonard AbbedutoAngela John Thurman
Apr 10, 2021·Journal of Chemical Neuroanatomy·Danielle N Jones, Mary Ann Raghanti

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