Brain natriuretic peptide (BNP) as a biomarker of myocardial ischemia-reperfusion injury in cardiac transplantation

Journal of Cardiothoracic and Vascular Anesthesia
David R McIlroyNicholas Roubos

Abstract

To evaluate brain natriuretic peptide (BNP) as a biomarker of ischemia-reperfusion injury in cardiac transplantation A prospective cohort study. A single academic medical center. Adult patients undergoing orthotopic cardiac transplantation (n = 25). None. The authors performed serial measurements of BNP and troponin-I in cardiac allograft donors and recipients, determining the relationship between these biomarkers and established risk factors for and measures of early graft dysfunction. Postoperative BNP correlated moderately with allograft ischemic time (ρ = 0.52, p = 0.01), donor BNP (ρ = 0.45, p = 0.03), and donor troponin-I (ρ = 0.49, p = 0.01). Postoperative BNP was higher in patients with persistently elevated inotrope requirements and enabled the early identification of such patients. In contrast, there was no association between postoperative troponin-I and these same parameters. Postoperative BNP is associated with preimplantation and clinical performance parameters related to allograft ischemia-reperfusion injury at the time of cardiac transplantation, providing preliminary evidence to support its potential use as an ischemia-reperfusion injury biomarker in this context.

References

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Citations

Jan 29, 2011·Journal of Cardiothoracic and Vascular Anesthesia·Michael AndritsosJohn G T Augoustides
Jun 13, 2014·Pediatric Transplantation·Joshua D SparksCharles E Canter
May 6, 2015·PloS One·Luca Salvatore De SantoCristiano Amarelli
Jun 28, 2012·International Anesthesiology Clinics·Kathirvel Subramaniam
Nov 3, 2021·The International Journal of Cardiovascular Imaging·Hakimeh SaadatifarSomayeh Pouriamehr

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