PMID: 11903396Mar 21, 2002Paper

Brain natriuretic peptide increases urinary albumin and alpha-1 microglobulin excretion in Type 1 diabetes mellitus

Diabetic Medicine : a Journal of the British Diabetic Association
K McKennaC J Thompson

Abstract

Atrial natriuretic peptide (ANP) increases urinary albumin excretion in Type 1 diabetes mellitus (DM). Brain natriuretic peptide (BNP) is structurally and functionally related to ANP, but its effect on urine albumin excretion rate (UAER) is unknown. To compare the albuminuric effects of intravenous infusion of ANP and BNP, and to assess the effect of both peptides on tubular protein excretion. Eight subjects with Type 1 DM were randomised to a three leg, double blind, and placebo controlled study. On each study day, subjects were euglycaemic clamped and subsequently water loaded (20 mL/kg orally, plus urine losses) to steady state diuresis. When in steady state, creatinine clearance was estimated in three separate 1 hour periods. At the end of the first period, a 1 hour intravenous infusion of either placebo, ANP 0.025 microg/kg/min, or BNP 0.025 microg/kg/min was administered. There followed a 1 hour recovery period. Urine was collected at 15 min intervals for estimation of urine albumin (ACR) and alpha1 microglobulin creatinine ratio (MCR). Results were analysed by anova. Creatinine clearance was similar on the three study days, and was unaltered by any infusion. ACR was unaltered by placebo (1.3 +/- 0.5-1.2 +/- 0.4 mg/mmol, ...Continue Reading

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Citations

May 8, 2002·Diabetes/metabolism Research and Reviews
Nov 16, 2005·Irish Journal of Medical Science·K McKennaC J Thompson
Dec 15, 2005·Heart, Lung & Circulation·David R SullivanRichmond Jeremy
Feb 29, 2016·Journal of Diabetes and Its Complications·Lingli ZhouLinong Ji
Jun 26, 2003·Diabetic Medicine : a Journal of the British Diabetic Association·A SiebenhoferT R Pieber
Oct 20, 2006·Journal of Clinical Pharmacology·Michael S KostapanosMoses Elisaf
Aug 24, 2013·Renal Failure·Hulya TaskapanSaim Yologlu
Jul 12, 2005·Endocrine Journal·Masahiko IgarashiMakoto Tominaga
Oct 25, 2011·Diabetes Research and Clinical Practice·Ramazan DanisOmer Alyan
Jun 26, 2010·Scandinavian Journal of Clinical and Laboratory Investigation·Jakob GrauslundAnne K Sjølie
Dec 21, 2016·Journal of Physics. Condensed Matter : an Institute of Physics Journal·A B DrovosekovV V Ustinov

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