Brain Network Organization and Social Executive Performance in Frontotemporal Dementia

Journal of the International Neuropsychological Society : JINS
Lucas SedeñoAgustin Ibanez

Abstract

Behavioral variant frontotemporal dementia (bvFTD) is characterized by early atrophy in the frontotemporoinsular regions. These regions overlap with networks that are engaged in social cognition-executive functions, two hallmarks deficits of bvFTD. We examine (i) whether Network Centrality (a graph theory metric that measures how important a node is in a brain network) in the frontotemporoinsular network is disrupted in bvFTD, and (ii) the level of involvement of this network in social-executive performance. Patients with probable bvFTD, healthy controls, and frontoinsular stroke patients underwent functional MRI resting-state recordings and completed social-executive behavioral measures. Relative to the controls and the stroke group, the bvFTD patients presented decreased Network Centrality. In addition, this measure was associated with social cognition and executive functions. To test the specificity of these results for the Network Centrality of the frontotemporoinsular network, we assessed the main areas from six resting-state networks. No group differences or behavioral associations were found in these networks. Finally, Network Centrality and behavior distinguished bvFTD patients from the other groups with a high classifi...Continue Reading

References

Apr 1, 1986·Annals of Neurology·M M Mesulam
Nov 18, 1997·Journal of Child Psychology and Psychiatry, and Allied Disciplines·S Baron-CohenM Robertson
Dec 18, 2001·Human Brain Mapping·Thomas E Nichols, Andrew P Holmes
Jun 13, 2003·The Journal of Head Trauma Rehabilitation·Skye McDonaldJulianne Kinch
Aug 21, 2004·Neuroinformatics·Olaf Sporns, Jonathan D Zwi
Mar 12, 2005·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Katherine P RankinBruce L Miller
Apr 27, 2005·Journal of the Neurological Sciences·Jillian J KrilGlenda M Halliday
Aug 10, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Christian F BeckmannStephen M Smith
Aug 11, 2006·Dementia and Geriatric Cognitive Disorders·Tiffany W ChowAnne M Lipton
Sep 2, 2006·Proceedings of the National Academy of Sciences of the United States of America·J S DamoiseauxC F Beckmann
May 23, 2007·Journal of Neuroscience Methods·Eric Maris, Robert Oostenveld
Feb 13, 2008·Archives of Neurology·William W SeeleyMaria Luisa Gorno-Tempini
Apr 24, 2008·PloS One·Martijn van den HeuvelHilleke Hulshoff Pol
May 2, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yong HeAlan Evans
Jun 28, 2008·PLoS Computational Biology·Kaustubh SupekarMichael D Greicius
Feb 13, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Randy L BucknerKeith A Johnson
Apr 3, 2009·Annals of the New York Academy of Sciences·Tania Singer, Claus Lamm
Jul 22, 2009·Proceedings of the National Academy of Sciences of the United States of America·Stephen M SmithChristian F Beckmann
Jul 29, 2009·Journal of the International Neuropsychological Society : JINS·Teresa TorralvaFacundo Manes
Sep 19, 2009·Brain : a Journal of Neurology·Jennifer L WhitwellKeith A Josephs
Oct 19, 2010·Brain : a Journal of Neurology·Matthew A Lambon RalphKaralyn Patterson
Dec 3, 2010·PLoS Computational Biology·Zhijun YaoUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Dec 15, 2010·Lancet Neurology·Olivier PiguetJohn R Hodges
Jan 22, 2011·Computational Intelligence and Neuroscience·Robert OostenveldJan-Mathijs Schoffelen
Feb 10, 2011·The Journal of Neuropsychiatry and Clinical Neurosciences·Paul J EslingerMurray Grossman
Jun 10, 2011·Annals of the New York Academy of Sciences·Jean Decety
Jul 23, 2011·Lancet Neurology·Michela PievaniGiovanni B Frisoni
Aug 4, 2011·NeuroImage·Koene R A Van DijkRandy L Buckner
Aug 4, 2011·Brain : a Journal of Neurology·Katya RascovskyBruce L Miller
Oct 5, 2011·Cerebral Cortex·Xi-Nian ZuoMichael P Milham
Apr 25, 2012·Neurology·Agustin Ibañez, Facundo Manes
Oct 11, 2012·Trends in Cognitive Sciences·Daniel P Kennedy, Ralph Adolphs
Oct 25, 2012·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Norman A S FarbTiffany W Chow
Nov 8, 2012·Frontiers in Human Neuroscience·Klaudius KalcherChristian Windischberger
Nov 21, 2012·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Massimo FilippiAndrea Falini

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Citations

Sep 13, 2016·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Tobias LuckSteffi G Riedel-Heller
Aug 9, 2016·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Sandra BaezAgustín Ibáñez
Sep 30, 2016·Brain : a Journal of Neurology·Margherita MelloniAgustín Ibáñez
Oct 7, 2016·Social Neuroscience·Agustín IbáñezFacundo Manes
Aug 3, 2017·Human Psychopharmacology·Alex DoruyterJames M Warwick
Sep 29, 2017·Neurology·Massimo FilippiFederica Agosta
Jan 7, 2018·Neurology·Mario A ParraAgustin Ibanez
Dec 4, 2019·Topics in Magnetic Resonance Imaging : TMRI·Rozita JalilianhasanpourHaris I Sair
Nov 15, 2016·Frontiers in Aging Neuroscience·Sandra Baez, Agustín Ibáñez
Aug 10, 2019·Frontiers in Aging Neuroscience·José Manuel Santacruz EscuderoHernando Santamaría-García
Jan 13, 2017·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Indira García-CorderoAgustín Ibañez
Jun 28, 2018·Frontiers in Neurology·Andrew R Carr, Mario F Mendez
Nov 8, 2017·Brain : a Journal of Neurology·Hernando Santamaría-GarcíaAgustín Ibáñez
Sep 5, 2020·Network Neuroscience·Roberto C SoteroMehdy Dousty
Sep 24, 2020·The European Journal of Neuroscience·Agustina LegazAgustín Ibañez
Feb 1, 2020·Neuroscience and Biobehavioral Reviews·Juan A AriasAndrew H Kemp
Jan 26, 2021·Journal of Alzheimer's Disease : JAD·Agustin IbanezUNKNOWN Latin America and the Caribbean Consortium on Dementia (LAC-CD)
Feb 10, 2021·Alzheimer's Research & Therapy·Lucy L RussellJonathan D Rohrer
Feb 10, 2021·Brain Sciences·Salvatore NigroGiancarlo Logroscino
May 12, 2021·Cognitive, Affective & Behavioral Neuroscience·Daniel Franco-O'ByrneSandra Baez
Sep 24, 2021·Frontiers in Neurology·Jorge J Llibre-GuerraRicardo Nitrini

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