Brain neuroreceptor density and personality traits: towards dimensional biomarkers for psychiatric disorders

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Lars FardeSimon Cervenka

Abstract

Positron emission tomography has, for 30 years, been used in numerous case-control studies searching for hypothesized differences in the density of neuroreceptor or transporter proteins in psychiatric disorders such as schizophrenia and depression. In most cases, the results have not been conclusive. One reason could be the sizeable interindividual variability in biochemical markers, which in twin studies have shown to emanate from both environmental and genetic factors, leading to low statistical power for the detection of group effects. On the other hand, the same interindividual variability has served as an opportunity for correlative studies on the biological underpinning of behaviour. Using this approach, a series of studies has linked markers for the dopamine and serotonin system to personality traits associated with psychiatric conditions. Based on increasing evidence for the view that many psychopathological states represent extremes of a continuum rather than distinct categories, this research strategy may lead to new biological insights about the vulnerability to and pathophysiology of major psychiatric disorders.This article is part of the theme issue 'Diverse perspectives on diversity: multi-disciplinary approaches ...Continue Reading

References

Aug 20, 1996·Proceedings of the National Academy of Sciences of the United States of America·M LaruelleR B Innis
Feb 13, 1997·Nature·L FardeE Jönsson
Mar 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·A BreierD Pickar
Dec 12, 1997·Acta Psychiatrica Scandinavica·J P GustavssonD Schalling
Oct 10, 1998·The American Journal of Psychiatry·A BreierD Pickar
Feb 15, 2000·The American Journal of Psychiatry·A LaaksoJ Hietala
May 3, 2002·The American Journal of Psychiatry·Per KarlssonGöran Sedvall
May 3, 2003·The American Journal of Psychiatry·Aki LaaksoJarmo Hietala
Nov 5, 2003·The American Journal of Psychiatry·Jacqueline BorgLars Farde
Apr 2, 2004·The American Journal of Psychiatry·Kenneth S KendlerCarol A Prescott
Sep 3, 2005·European Psychiatry : the Journal of the Association of European Psychiatrists·Chieh Liang HuangNan Tsing Chiu
Jan 27, 2006·International Clinical Psychopharmacology·Anna Wirz-Justice
Mar 6, 2007·Biological Psychiatry·Akihiro TakanoTetsuya Suhara
May 24, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Robert B InnisRichard E Carson
Sep 10, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Jussi HirvonenHarry Scheinin
Dec 4, 2008·Nature Reviews. Neuroscience·Paul C Fletcher, Chris D Frith
Jan 2, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·David H ZaldRobert M Kessler
Jan 7, 2009·Archives of General Psychiatry·Oliver D HowesPaul M Grasby
Jan 13, 2009·NeuroImage·Jan KalbitzerGitte M Knudsen
Oct 9, 2009·Biological Psychiatry·Diana MartinezHerbert D Kleber
Jun 1, 2006·Current Psychiatry Reports·Daniel Freeman
Dec 5, 2009·Psychiatry Research·Paul H SoloffCarolyn C Meltzer
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Albert GjeddeArne Møller

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Citations

Apr 17, 2019·Personality and Mental Health·José E Muñoz-NegroJorge A Cervilla
Feb 28, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Irina Trofimova
Feb 28, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·I TrofimovaJ Uher
Feb 28, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·T W Robbins
Feb 28, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Jana UherLouis A Schmidt
Dec 13, 2019·Proceedings of the National Academy of Sciences of the United States of America·Francesca MelozziChristophe Bernard
Apr 30, 2020·PloS One·Mădălina Elena CostacheTomas Furmark
Aug 26, 2020·Human Brain Mapping·Qiang XuChunshui Yu
May 15, 2019·Current Opinion in Neurology·Sabine Hellwig, Katharina Domschke
Feb 28, 2021·Journal of Psychiatric Research·Roser GraneroSusana Jiménez-Murcia

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