Brain-on-a-chip Devices for Drug Screening and Disease Modeling Applications

Current Pharmaceutical Design
Beatrice MiccoliYi-Chen Ethan Li

Abstract

Neurodegenerative disorders are related to the progressive functional loss of the brain, often connected to emotional and physical disability and, ultimately, to death. These disorders, strongly connected to the aging process, are becoming increasingly more relevant due to the increase of life expectancy. Current pharmaceutical treatments poorly tackle these diseases, mainly acting only on their symptomology. One of the main reasons of this is the current drug development process, which is not only expensive and time-consuming but, also, still strongly relies on animal models at the preclinical stage. Organ-on-a-chip platforms have the potential to strongly impact and improve the drug screening process by recreating in vitro the functionality of human organs. Patient-derived neurons from different regions of the brain can be directly grown and differentiated on a brain-on-a-chip device where the disease development, progression and pharmacological treatments can be studied and monitored in real time. The model reliability is strongly improved by using human-derived cells, more relevant than animal models for pharmacological screening and disease monitoring. The selected cells will be then capable of proliferating and organizing...Continue Reading

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Citations

Apr 24, 2019·Current Pharmaceutical Design·Kai Zhu, Yi-Chen Ethan Li
Jul 3, 2019·Molecular Neurobiology·Mirza Ali Mofazzal JahromiMichael R Hamblin
Mar 10, 2020·Lab on a Chip·Yanan ZhaoPu Chen
Oct 1, 2020·International Journal of Molecular Sciences·Georgia KouroupiRebecca Matsas
Feb 9, 2021·Expert Review of Clinical Pharmacology·Yadollah OmidiHossein Omidian
Dec 31, 2020·Micromachines·Rahman Sabahi-Kaviani, Regina Luttge
Mar 7, 2021·Pathogens·Buket Baddal, Pasquale Marrazzo
Jul 18, 2020·Trends in Microbiology·Huaqi TangAlireza Mashaghi
Jul 20, 2021·Journal of Neural Engineering·Martina BrofigaPaolo Massobrio
Aug 15, 2021·Biotechnology Journal·Devashree JahagirdarPrajakta Dandekar

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