Brain opioid receptor binding of [3H]CTOP and [3H]naltrindole in alcohol-preferring AA and alcohol-avoiding ANA rats

Alcohol
Sanna L SoiniEsa R Korpi

Abstract

We compared mu- and delta-opioid receptor distributions between the brains of alcohol-preferring Alko, Alcohol (AA) and alcohol-avoiding Alko, Non-Alcohol (ANA) rat lines, using autoradiography on brain sections with mu- and delta-opioid receptor antagonist ligands [3H]CTOP and [3H]naltrindole, respectively. The labeling patterns of the ligands were consistent with the known opioid receptor distributions in both rat lines and no major genetic differences were found between the lines. However, the binding density of mu- and delta-opioid receptors differed slightly in several brain areas: in the AA brain sections, limbic areas, such as hippocampus and amygdala, showed decreased mu- and delta-opioid receptor binding, whereas the striatal patches were larger and the substantia nigra showed higher binding density of the mu-receptors compared to the ANA sections. The small differences observed between the rat lines could be due to adaptations to altered endogenous opioid peptide levels or neural circuits, and associated with the differences in alcohol drinking or other behaviors.

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Citations

Jan 3, 2001·European Journal of Pharmacology·T TownM Mullan
Jul 30, 2002·European Journal of Pharmacology·Sanna L SoiniEsa R Korpi
Feb 13, 2001·Pharmacology, Biochemistry, and Behavior·J A MikkolaL Ahtee
Aug 2, 2002·Pharmacology, Biochemistry, and Behavior·Janne A V MikkolaLiisa Ahtee
Mar 4, 2000·Peptides·A L VaccarinoA J Kastin
Dec 3, 1999·Progress in Neuro-psychopharmacology & Biological Psychiatry·M S Cowen, A J Lawrence
May 10, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Elise M WeertsMary E McCaul
Sep 12, 2006·Addiction Biology·Richard L BellWilliam J McBride
Feb 13, 2010·Addiction Biology·John C CrabbeCindy L Ehlers
Sep 2, 1999·Alcoholism, Clinical and Experimental Research·P FaddaW Fratta
Feb 24, 2001·Alcoholism, Clinical and Experimental Research·P Hyytiä, K Kiianmaa
Jun 8, 2001·Alcoholism, Clinical and Experimental Research·A D LêJ C Crabbe
Aug 16, 2005·CNS Drugs·Vania Modesto-Lowe, Eleanor M Fritz
Jun 22, 2011·Alcoholism, Clinical and Experimental Research·Elise M WeertsMary E McCaul
May 26, 2004·Physiology & Behavior·L M Oswald, G S Wand

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