Brain organization and sleep function

Behavioural Brain Research
J M KruegerJ Fang

Abstract

A view of brain organization and sleep function is presented. Sleep is hypothesized to begin at the neuronal group level. Sleep results in the use and thus maintenance, of synapses that are insufficiently stimulated during wakefulness thereby serving to preserve a constancy of a synaptic superstructure. It is further hypothesized that sleep at the neuronal group level is regulated by the production of substances whose rate of production or catabolism is synaptic use-dependent. If sufficient number of neuronal groups are in a sleep state (also called disjunctive state) then the perception of sleepiness occurs. Coordination of neuronal group sleep results from humoral and neuronal projection systems previously linked to sleep regulation. The theory presented is unique in that it: (a) hypothesizes an organizational level at which sleep occurs; (b) hypothesizes that sleep is neuronal--use-dependent, not wakefulness-dependent; (c) hypothesizes that sleep first occurs in evolution when complex ganglia evolved; and (d) hypothesizes the both non-rapid eye movement sleep (NREMS) and REMS serve the same function of synaptic reorganization. The theory is consistent with past theories of sleep function, yet provides a fundamentally new par...Continue Reading

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Citations

Jan 1, 1996·Neuroscience and Biobehavioral Reviews·J L Kavanau
Jul 1, 1995·Behavioural Brain Research·A GiudittaS Vescia
Mar 2, 2005·Sleep Medicine Reviews·J Lee Kavanau
Jan 5, 2002·Behavioural Brain Research·Jose L CanteroRosa M Salas
May 29, 1998·Brain Research. Molecular Brain Research·C Cirelli, G Tononi
Apr 10, 2003·Progress in Neurobiology·Joel H Benington, Marcos G Frank
May 13, 1999·Neuroscience Letters·S Takahashi, J M Krueger
Jan 1, 1997·Brain Research Bulletin·J L Kavanau
Aug 18, 2004·Sleep Medicine Reviews·J M KruegerJ Fang
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Apr 24, 2008·Genetics·Susan T Harbison, Amita Sehgal
Nov 6, 2013·Pharmacology & Therapeutics·M DreslerF Holsboer
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Mar 15, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·T KushikataJ M Krueger
Aug 4, 1998·The American Journal of Physiology·T KushikataJ M Krueger

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