Brain Organoids as Tools for Modeling Human Neurodevelopmental Disorders

Physiology
Jason W AdamsAlysson R Muotri

Abstract

Brain organoids recapitulate in vitro the specific stages of in vivo human brain development, thus offering an innovative tool by which to model human neurodevelopmental disease. We review here how brain organoids have been used to study neurodevelopmental disease and consider their potential for both technological advancement and therapeutic development.

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Citations

Aug 8, 2019·Physiology·Gary C Sieck
Mar 8, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Agustín Cota-CoronadoN Emmanuel Díaz-Martínez
Nov 17, 2020·Frontiers in Cell and Developmental Biology·Yikai ShouXuekun Li
Jan 28, 2021·EMBO Molecular Medicine·Cleber A TrujilloAlysson R Muotri
Jun 29, 2021·Frontiers in Physiology·Evanthia A Makrygianni, George P Chrousos

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Methods Mentioned

BETA
MDS
atomic force microscopy

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