PMID: 9533610Apr 9, 1998Paper

Brain "ouabain", a neurosteroid, mediates sympathetic hyperactivity in salt-sensitive hypertension

Clinical and Experimental Hypertension : CHE
A S BudzikowskiF H Leenen

Abstract

This review addresses recent developments in the neurobiology of an endogenous inhibitor of brain Na+, K+ - ATPase, "ouabain". "Ouabain" is present in hypothalamic and medullary neurons and mediates sympathoexcitatory and pressor responses to acute and chronic increases in cerebrospinal fluid (CSF) sodium concentration as well as mediates the sympathoexcitatory and pressor responses to high dietary sodium intake in SHR and Dahl-S rats, and sympathetic hyperactivity in the congestive heart failure. Some of these actions of "ouabain" in the CNS take place in the median preoptic nucleus and ventral part of the AV3V region. Despite recent advances in unveiling a biological role for "ouabain" its structure, biosynthetic and metabolic pathways as well as actual control mechanisms remain unresolved.

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Citations

May 17, 2001·Current Hypertension Reports·J M Wyss, S H Carlson
Sep 12, 2000·Current Hypertension Reports·J M Wyss, S H Carlson
Dec 24, 2009·Canadian Journal of Physiology and Pharmacology·Katherine V WestcottFrans H H Leenen
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Apr 25, 2015·Advances in Chronic Kidney Disease·John M Hamlyn, Paolo Manunta
Sep 12, 2016·Current Hypertension Reports·Rossella IatrinoLaura Zagato
May 4, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jessica Venugopal, Gustavo Blanco
Oct 2, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Bing S HuangFrans H H Leenen
Apr 11, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Bing S HuangFrans H H Leenen
Aug 19, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Sergei N Orlov, Alexander A Mongin
Aug 23, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Hao WangFrans H H Leenen
Jul 12, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Hao WangFrans H H Leenen

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