Brain oxygenation responses to an autonomic challenge: a quantitative fMRI investigation of the Valsalva manoeuvre

Age
Iwo BohrAndrew M Blamire

Abstract

In late age, the autonomic nervous system (ANS) has diminished ability to maintain physiological homeostasis in the brain in response to challenges such as to systemic blood pressure changes caused by standing. We devised an fMRI experiment aiming to map the cerebral effects of an ANS challenge (Valsalva manoeuvre (VM)). We used dual-echo fMRI to measure the effective transverse relaxation rate (R2*, which is inversely proportional to brain tissue oxygenation levels) in 45 elderly subjects (median age 80 years old, total range 75-89) during performance of the VM. In addition, we collected fluid-attenuated inversion recovery (FLAIR) data from which we quantified white matter hyperintensity (WMH) volumes. We conducted voxelwise analysis of the dynamic changes in R2* during the VM to determine the distribution of oxygenation changes due to the autonomic stressor. In white matter, we observed significant decreases in oxygenation levels. These effects were predominantly located in posterior white matter and to a lesser degree in the right anterior brain, both concentrated around the border zones (watersheds) between cerebral perfusion territories. These areas are known to be particularly vulnerable to hypoxia and are prone to format...Continue Reading

References

Mar 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·G H GloverJ M Pauly
Feb 4, 1999·Journal of Applied Physiology·S L DawsonJ F Potter
Apr 13, 2000·Journal of the International Neuropsychological Society : JINS·D Caine, J D Watson
Mar 20, 2002·Cerebrovascular Diseases·Leonardo Pantoni
Oct 23, 2002·Human Brain Mapping·Stephen M Smith
Nov 16, 2002·Journal of Applied Physiology·Luke A HendersonRonald M Harper
Dec 6, 2002·Journal of Neurophysiology·Luke A HendersonRonald M Harper
Mar 8, 2003·Stroke; a Journal of Cerebral Circulation·J M WardlawJ Starr
Apr 17, 2004·Stroke; a Journal of Cerebral Circulation·Shari R WaldsteinLeslie I Katzel
Oct 27, 2004·NeuroImage·Stephen M SmithPaul M Matthews
Jun 16, 2005·NeuroImage·John Ashburner, Karl J Friston
Mar 15, 2006·Archives of Internal Medicine·Simon R J KerrRose Anne Kenny
Apr 22, 2006·Stroke; a Journal of Cerebral Circulation·Malee S FernandoUNKNOWN MRC Cognitive Function and Ageing Neuropathology Study Group
Jan 31, 2008·Practical Neurology·Mike O'Sullivan
Feb 6, 2008·Cardiovascular Research·François FeihlBernard Waeber
May 3, 2008·Stroke; a Journal of Cerebral Circulation·Daniel M MandellDavid J Mikulis
Jun 20, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Julia L NewtonDavid Jones
Dec 9, 2008·NeuroImage·Mark W WoolrichStephen M Smith
Aug 1, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Samantha GalluzziGiovanni B Frisoni
Aug 28, 2009·Journal of Neurology, Neurosurgery, and Psychiatry·R TopakianH S Markus
Oct 31, 2009·AJNR. American Journal of Neuroradiology·A L WentlandA S Field
Jan 28, 2010·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Jonathan RichardsonAlan J Thomas
Sep 21, 2010·Journal of Neurosurgery·Luigi Andrea LanternaFrancesco Biroli
Sep 16, 2011·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Rajiv ManglaSven E Ekholm
Dec 21, 2011·Postgraduate Medical Journal·Basil E Grueter, Ursula G Schulz
May 10, 2013·American Journal of Therapeutics·Lawrence C PerlmuterAron D Mosnaim

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Citations

Feb 10, 2016·Frontiers in Neuroscience·Paul M MaceyRonald M Harper
Aug 29, 2019·JDR Clinical and Translational Research·Q C VuongJ Durham

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