Brain oxytocin: how puzzle stones from animal studies translate into psychiatry.

Molecular Psychiatry
Valery Grinevich, I D Neumann

Abstract

The neuropeptide oxytocin has attracted great attention of the general public, basic neuroscience researchers, psychologists, and psychiatrists due to its profound pro-social, anxiolytic, and "anti-stress" behavioral and physiological effects, and its potential application for treatment of mental diseases associated with altered socio-emotional competence. During the last decade, substantial progress has been achieved in understanding the complex neurobiology of the oxytocin system, including oxytocinergic pathways, local release patterns, and oxytocin receptor distribution in the brain, as well as intraneuronal oxytocin receptor signaling. However, the picture of oxytocin actions remains far from being complete, and the central question remains: "How does a single neuropeptide exert such pleotropic actions?" Although this phenomenon, typical for many of about 100 identified neuropeptides, may emerge from the anatomical divergence of oxytocin neurons, their multiple central projections, distinct oxytocin-sensitive cell types in different brain regions, and multiple intraneuronal signaling pathways determining the specific cellular response, further basic studies are required. In conjunction, numerous reports on positive effects...Continue Reading

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Citations

Oct 3, 2020·Frontiers in Human Neuroscience·Alan R Harvey
Sep 29, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Nina MarshRené Hurlemann
Oct 7, 2020·Proceedings of the National Academy of Sciences of the United States of America·Natalia Duque-WilckensBrian C Trainor
Jan 30, 2021·Life Sciences·Stephani C Wang, Yu-Feng Wang
Mar 12, 2021·Frontiers in Psychiatry·Caroline J Smith, Staci D Bilbo
Oct 20, 2020·Frontiers in Neuroscience·Erin C McKay, Scott E Counts
Jun 3, 2021·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Bernd LenzChristiane Mühle
May 27, 2021·Molecular Psychiatry·Julia WinterInga D Neumann
Jun 9, 2021·Neuroscience and Biobehavioral Reviews·Andrey E Ryabinin, Hannah D Fulenwider
Jun 19, 2021·Hormones and Behavior·Martina StockerJorg J M Massen
Jul 25, 2021·International Journal of Molecular Sciences·Liya Kerem, Elizabeth A Lawson
Jul 21, 2021·Trends in Cognitive Sciences·Sylvia WirthAngela Sirigu
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Aug 28, 2021·International Journal of Molecular Sciences·Mohammad Saied SalehiSareh Pandamooz
Oct 30, 2021·Journal of Neuroendocrinology·Tatsushi Onaka, Yuki Takayanagi

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BETA
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