Brain perfusion abnormalities in chronic obstructive pulmonary disease: comparison with cognitive impairment

Annals of Nuclear Medicine
Hulya Ortapamuk, Seniha Naldoken

Abstract

To clarify cerebral perfusion distribution and cognitive functions in patients with chronic obstructive pulmonary disease (COPD) according to the hypoxia levels and to assess if there is a relationship between cognitive impairment and cerebral perfusion index. Eight patients with stable hypoxemic COPD (HC), 10 patients with stable nonhypoxemic COPD (NHC), and 10 age-matched healthy volunteers participated in the study. All subjects underwent a complete neuropsychological assessment with the mental deterioration battery (MDB), Wechsler memory scale-revised (WMS-R), color trail test (CCT), and grooved pegboard test (GPT). SPECT examination with Tc-99m HMPAO was performed in all patients and controls. Quantitative analysis was performed by a region of interest (ROI)-based method. The scores of verbal memory, delayed recall and attention were significantly lower in COPD patients (p < 0.01). The scores of other subtests were similar in patients and controls. Comparing NHC patients to HC groups showed that verbal memory was impaired in both groups, but delayed recall and attention scores were significantly worse in HC patients than NHC patients. Perfusion indexes on frontal ROIs in NHC patients and frontal and parietal ROIs in HC pat...Continue Reading

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Citations

Feb 27, 2013·Neuroradiology·Yasuyuki TakiHiroshi Fukuda
Oct 22, 2008·Journal of Clinical and Experimental Neuropsychology·Raffaele Antonelli-IncalziFranco Rengo
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