Brain perfusion in polysubstance users: relationship to substance and tobacco use, cognition, and self-regulation

Drug and Alcohol Dependence
Donna E MurrayDieter J Meyerhoff

Abstract

Brain perfusion is altered in both alcohol dependence and stimulant dependence. Although most substance users also abuse/depend on alcohol concurrently (polysubstance users; PSU), rigorous perfusion research in PSU is limited. Also, the relationships of perfusion abnormalities with cognition, impulsivity, or decision making are not well known. Arterial spin labeling MRI and neuropsychological measures assessed perfusion levels and neurocognition in 20 alcohol-dependent individuals with comorbid-stimulant dependence (PSU), 26 individuals dependent on alcohol only (ALC), and 31 light/non-drinking controls (LD). The patient groups included smokers and non-smokers. ALC had lower perfusion than LD in subcortical and cortical brain regions including the brain reward/executive oversight system (BREOS). Contrary to our hypothesis, regional perfusion was generally not lower in PSU than ALC. However, smoking PSU had lower perfusion than smoking ALC in several regions, including BREOS. Lower BREOS perfusion related to greater drinking severity in smoking substance users and to greater smoking severity in smoking ALC. Lower regional perfusion in ALC and PSU correlated with worse performance in different cognitive domains; smoking status af...Continue Reading

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Citations

Jul 21, 2015·International Journal of Environmental Research and Public Health·Timothy C DurazzoDonna E Murray
Mar 30, 2019·Alcoholism, Clinical and Experimental Research·Kelly E CourtneyMarc A Schuckit
Jun 30, 2018·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Hinesh TopiwalaCraig W Ritchie
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Feb 17, 2021·Journal of Psychiatric Research·Edith V SullivanAdolf Pfefferbaum
Feb 17, 2021·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Jessica R CanningMary E Larimer

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