Brain Perivascular Macrophages Initiate the Neurovascular Dysfunction of Alzheimer Aβ Peptides

Circulation Research
Laibaik ParkCostantino Iadecola

Abstract

Increasing evidence indicates that alterations of the cerebral microcirculation may play a role in Alzheimer disease, the leading cause of late-life dementia. The amyloid-β peptide (Aβ), a key pathogenic factor in Alzheimer disease, induces profound alterations in neurovascular regulation through the innate immunity receptor CD36 (cluster of differentiation 36), which, in turn, activates a Nox2-containing NADPH oxidase, leading to cerebrovascular oxidative stress. Brain perivascular macrophages (PVM) located in the perivascular space, a major site of brain Aβ collection and clearance, are juxtaposed to the wall of intracerebral resistance vessels and are a powerful source of reactive oxygen species. We tested the hypothesis that PVM are the main source of reactive oxygen species responsible for the cerebrovascular actions of Aβ and that CD36 and Nox2 in PVM are the molecular substrates of the effect. Selective depletion of PVM using intracerebroventricular injection of clodronate abrogates the reactive oxygen species production and cerebrovascular dysfunction induced by Aβ applied directly to the cerebral cortex, administered intravascularly, or overproduced in the brain of transgenic mice expressing mutated forms of the amyloi...Continue Reading

References

May 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·C Iadecola
Feb 11, 1998·Physiological Reviews·F M Faraci, D D Heistad
Aug 16, 2000·Proceedings of the National Academy of Sciences of the United States of America·K NiwaC Iadecola
Jun 14, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Kiyoshi NiwaCostantino Iadecola
Feb 8, 2003·Stroke; a Journal of Cerebral Circulation·Costantino Iadecola, Philip B Gorelick
Apr 20, 2004·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Laibaik ParkCostantino Iadecola
Apr 22, 2004·Nature Reviews. Neuroscience·Costantino Iadecola
Feb 18, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Laibaik ParkCostantino Iadecola
Jun 2, 2005·Annals of Neurology·Annemieke RuitenbergMonique M B Breteler
Dec 21, 2005·Neuron·John R CirritoDavid M Holtzman
Jan 19, 2008·Proceedings of the National Academy of Sciences of the United States of America·Laibaik ParkCostantino Iadecola
Dec 17, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Byung Hee HanGregory J Zipfel
Jan 24, 2009·Proceedings of the National Academy of Sciences of the United States of America·Cheryl A Hawkes, Joanne McLaurin
May 28, 2009·Science Signaling·Roy L Silverstein, Maria Febbraio
Aug 22, 2009·Stroke; a Journal of Cerebral Circulation·Meritxell GomisAntoni Dávalos
Feb 16, 2010·Neuron·Jordi SerratsPaul E Sawchenko
Oct 16, 2010·Neuropathology and Applied Neurobiology·W R Brown, C R Thore
Mar 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Laibaik ParkCostantino Iadecola
Aug 5, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alexander MildnerMarco Prinz
Nov 4, 2011·Nature Reviews. Neuroscience·Berislav V Zlokovic
Apr 12, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Xin-Kang TongEdith Hamel
Aug 21, 2012·Nature Reviews. Immunology·Richard M Ransohoff, Britta Engelhardt
Dec 4, 2012·Stroke; a Journal of Cerebral Circulation·Laibaik ParkCostantino Iadecola
Jan 12, 2013·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Martin PrinceCleusa P Ferri
Feb 6, 2013·Proceedings of the National Academy of Sciences of the United States of America·Laibaik ParkCostantino Iadecola
May 8, 2013·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Paulo W PiresAnne M Dorrance
Nov 26, 2013·Neuron·Costantino Iadecola
Dec 21, 2013·European Heart Journal·Zvonimir S Katusic, Susan A Austin
Jan 5, 2014·Stroke; a Journal of Cerebral Circulation·Joan Martí-FàbregasAlberto Lleó
Aug 28, 2014·Journal of Alzheimer's Disease : JAD·Christina E WierengaZvinka Z Zlatar
Feb 18, 2015·Nature Immunology·Michael T HenekaEicke Latz
Sep 4, 2015·Cellular and Molecular Neurobiology·Kenzo KoizumiLaibaik Park
Nov 6, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lidia Garcia-BonillaCostantino Iadecola
Feb 13, 2016·Cell·Bart De Strooper, Eric Karran
Feb 28, 2016·Lancet·Philip ScheltensWiesje Maria Van der Flier

❮ Previous
Next ❯

Citations

May 31, 2018·Hypertension·Daniel A Nation
Jun 9, 2018·Circulation Research·Ruth Williams
Feb 16, 2018·Immunity & Ageing : I & a·Giuseppe GiuglianoValentina Trimarco
Nov 23, 2018·Acta Neuropathologica·Madelyn E McCauley, Robert H Baloh
Sep 3, 2019·Frontiers in Neurology·Şefik Evren Erdener, Turgay Dalkara
Aug 7, 2017·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Giuseppe FaracoCostantino Iadecola
Jan 20, 2018·Cardiovascular Research·Juhana Frösen, Anne Joutel
Nov 21, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Sébastien Foulquier
Jul 23, 2019·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Vladimir HachinskiZaven S Khachaturian
May 3, 2019·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Farshid SepehrbandArthur W Toga
Nov 3, 2017·Current Opinion in Neurology·Yasser Iturria-MedinaAlan C Evans
May 20, 2020·Scientific Reports·Shahzad AhmadCornelia M van Duijn
Aug 28, 2019·Scientific Reports·Farshid SepehrbandArthur W Toga
Sep 1, 2020·Acta Neuropathologica·Nils KorteDavid Attwell
Aug 22, 2018·Nature Reviews. Immunology·Antonio LapennaClaire E Lewis
Sep 21, 2018·Nature Communications·Kenzo KoizumiCostantino Iadecola
Dec 7, 2018·Frontiers in Aging Neuroscience·Feixue WangHao Li
Mar 26, 2019·Current Alzheimer Research·Evi Paouri, Spiros Georgopoulos
Dec 28, 2019·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Fanny M ElahiJoel H Kramer
Apr 23, 2019·European Stroke Journal·S DebetteUNKNOWN European Stroke Science Workshop Presenters and Co-convenors
Sep 22, 2019·International Journal of Molecular Sciences·Baruh PolisAbraham O Samson
Nov 22, 2019·CNS Neuroscience & Therapeutics·Tuo YangFeng Zhang
Dec 6, 2019·Frontiers in Neuroanatomy·Virginia CipolliniCostantino Iadecola
Sep 24, 2019·International Journal of Stroke : Official Journal of the International Stroke Society·Vladimir HachinskiZaven S Khachaturian
May 5, 2018·Cardiovascular Research·Rosalind BrownJoanna M Wardlaw
Jun 4, 2020·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Rune B NielsenSimon F Eskildsen
Jan 16, 2019·Nature Reviews. Neuroscience·Christopher M HenstridgeTara L Spires-Jones
Jul 31, 2019·Nature Reviews. Neuroscience·Katrin KierdorfMarco Prinz
Aug 20, 2019·Postgraduate Medicine·Pitchaya WanleenuwatWojciech Kozubski
May 15, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Mustafa BalkayaSunghee Cho
Nov 26, 2020·BMC Biology·Xavier Gallart-PalauSiu Kwan Sze
Nov 27, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Monica Gireud-GossAkihiko Urayama
Jan 15, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hoyee WanR Loch Macdonald
Nov 20, 2020·Neuroscience·Ana-Maria DobriMihail Eugen Hinescu
Feb 5, 2021·Frontiers in Cellular Neuroscience·Joe SteinmanZhong-Ping Feng
Dec 18, 2020·Frontiers in Aging Neuroscience·Season K Wyatt-Johnson, Randy R Brutkiewicz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Animal Models

Alzheimer's disease is a neurodegenerative disease which can be studied using various experimental systems. This feed focuses on animal models used for Alzheimer's disease research.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Laibaik ParkCostantino Iadecola
Proceedings of the National Academy of Sciences of the United States of America
Laibaik ParkCostantino Iadecola
Proceedings of the National Academy of Sciences of the United States of America
Laibaik ParkCostantino Iadecola
© 2022 Meta ULC. All rights reserved