Brain Phospholipid Precursors Administered Post-Injury Reduce Tissue Damage and Improve Neurological Outcome in Experimental Traumatic Brain Injury

Journal of Neurotrauma
Orli Thau-ZuchmanAdina T Michael-Titus

Abstract

Traumatic brain injury (TBI) leads to cellular loss, destabilization of membranes, disruption of synapses and altered brain connectivity, and increased risk of neurodegenerative disease. A significant and long-lasting decrease in phospholipids (PLs), essential membrane constituents, has recently been reported in plasma and brain tissue, in human and experimental TBI. We hypothesized that supporting PL synthesis post-injury could improve outcome post-TBI. We tested this hypothesis using a multi-nutrient combination designed to support the biosynthesis of PLs and available for clinical use. The multi-nutrient, Fortasyn® Connect (FC), contains polyunsaturated omega-3 fatty acids, choline, uridine, vitamins, cofactors required for PL biosynthesis, and has been shown to have significant beneficial effects in early Alzheimer's disease. Male C57BL/6 mice received a controlled cortical impact injury and then were fed a control diet or a diet enriched with FC for 70 days. FC led to a significantly improved sensorimotor outcome and cognition, reduced lesion size and oligodendrocyte loss, and it restored myelin. It reversed the loss of the synaptic protein synaptophysin and decreased levels of the axon growth inhibitor, Nogo-A, thus creat...Continue Reading

References

Mar 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R A SwansonF R Sharp
Jan 1, 1985·Progress in Lipid Research·P S Sastry
Jul 1, 1997·Journal of Neurochemistry·P HomayounN G Bazan
Aug 2, 2001·Journal of Molecular Neuroscience : MN·A A Spector
May 16, 2002·Acta Neuropathologica·Helen M Bramlett, W Dalton Dietrich
Jan 8, 2003·Neurochemical Research·A D PurdonS I Rapoport
May 15, 2003·Journal of Neurosurgery·Douglas H SmithDavid I Graham
Oct 7, 2003·Neuromolecular Medicine·Douglas H SmithTracy K McIntosh
Jan 22, 2004·Nature Reviews. Neuroscience·Jerry Silver, Jared H Miller
Jun 9, 2004·Neurobiology of Learning and Memory·Rebecca S HammondRobert W Stackman
Jan 26, 2005·The Journal of Head Trauma Rehabilitation·John T Povlishock, Douglas I Katz
Jul 12, 2005·Journal of Neurotrauma·S W ScheffC Brackney
Aug 30, 2005·Brain Research·Mehmet CansevRichard J Wurtman
Dec 15, 2005·Neuropsychologia·Mar ArizaJuan Sahuquillo
Apr 6, 2006·Neuropsychology·Jennifer Clare SaundersRick Richardson
Jul 11, 2006·Brain : a Journal of Neurology·D J MyerM V Sofroniew
Aug 1, 2006·Experimental Neurology·Radoslaw RolaJohn R Fike
Nov 24, 2006·The Journal of Head Trauma Rehabilitation·Wesley Rutland-BrownYongli Lily Xi
Jan 25, 2007·Neurosurgery Clinics of North America·R Mark RichardsonM Ross Bullock
Jul 10, 2007·Progress in Brain Research·Corinna Van Den HeuvelRobert Vink
Sep 7, 2007·Methods and Findings in Experimental and Clinical Pharmacology·S K KulkarniM Bishnoi
Nov 28, 2007·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Craig E Brown, Timothy H Murphy
Dec 14, 2007·Journal of Rehabilitation Research and Development·William C Walker, Treven C Pickett
Apr 1, 2008·Pharmacology & Therapeutics·Ming-Kai Chen, Tomás R Guilarte
Jul 19, 2008·Lancet Neurology·Andrew I R MaasRoss Bullock
Nov 26, 2008·Journal of Leukocyte Biology·Bart R TambuyzerEtienne J Nouwen
Apr 30, 2009·Annual Review of Nutrition·Richard J WurtmanIsmail H Ulus
Aug 26, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·P J Kamphuis, R J Wurtman

❮ Previous
Next ❯

Citations

Feb 8, 2019·Frontiers in Behavioral Neuroscience·Juliana PopovitzHita Adwanikar
Mar 20, 2019·Current Reviews in Musculoskeletal Medicine·Anjali GuptaCarlin Senter
Oct 28, 2020·Journal of Neuroscience Research·Joshua P McGeownRobert Borotkanics
Oct 11, 2020·Seminars in Cell & Developmental Biology·Isabell Nessel, Adina T Michael-Titus
Oct 15, 2020·Journal of Neurotrauma·Juliana PopovitzHita Adwanikar

❮ Previous
Next ❯

Key Resources (RRID) Mentioned

SCR_004074
SCR_014289
AB_973414
AB_10013382
AB_839504
AB_10862345
AB_2057371
AB_2341188
AB_1586992
SCR_014198

Software Mentioned

Adobe Illustrator
JVP AutoColourCellCountsRev
ChemStation
GraphPad
Bioseb
ImageJ
CatWalk XT
Adobe
Illustrator
ZENlite

Related Concepts

Related Feeds

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Alzheimer's Disease: Microglia

Microglia are a type of glial cell found throughout the brain and spinal cord. Microglia have been found to be associated with Alzheimer's disease development and progression. Here are the latest discoveries pertaining to Alzheimer's disease and microglia.