Brain receptor mosaics and their intramembrane receptor-receptor interactions: molecular integration in transmission and novel targets for drug development

Journal of Acupuncture and Meridian Studies
K FuxeL F Agnati

Abstract

The concept of intramembrane receptor-receptor interactions and evidence for their existence was introduced by Agnati and Fuxe in 1980/81 suggesting the existence of heteromerization of receptors. In 1982, they proposed the existence of aggregates of multiple receptors in the plasma membrane and coined the term receptor mosaics (RM). In this way, cell signaling becomes a branched process beginning at the level of receptor recognition at the plasma membrane where receptors can directly modify the ligand recognition and signaling capacity of the receptors within a RM. Receptor-receptor interactions in RM are classified as operating either with classical cooperativity, when consisting of homomers or heteromers of similar receptor subtypes having the same transmitter, or non-classical cooperativity, when consisting of heteromers. It has been shown that information processing within a RM depends not only on its receptor composition, but also on the topology and the order of receptor activation determined by the concentrations of the ligands and the receptor properties. The general function of RM has also been demonstrated to depend on allosteric regulators (e.g., homocysteine) of the receptor subtypes present. RM as integrative node...Continue Reading

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Citations

Oct 10, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kjell FuxeLuigi F Agnati
Nov 11, 2014·Expert Opinion on Therapeutic Targets·Diego GuidolinKjell Fuxe
Mar 30, 2010·CNS Neuroscience & Therapeutics·K FuxeL F Agnati
May 1, 2010·Journal of Receptor and Signal Transduction Research·Luigi F AgnatiKjell Fuxe
Jul 28, 2015·Neuropharmacology·Gemma NavarroRafael Franco
Feb 22, 2018·Reviews in the Neurosciences·Diego GuidolinLuigi F Agnati
Oct 3, 2015·The British Journal of Psychiatry : the Journal of Mental Science·Vasiliki OrgetaMartin Orrell
Jul 27, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ahmed HasbiSusan R George
Mar 6, 2019·Frontiers in Endocrinology·Diego GuidolinLuigi F Agnati
Jan 15, 2019·Journal of Neural Transmission·Dasiel O Borroto-Escuela, Kjell Fuxe
Jan 29, 2021·International Journal of Molecular Sciences·Thu Hang LaiPeter Brust
Apr 10, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Desye Misganaw
Sep 21, 2021·Epilepsia Open·Daniel Fonseca-BarriendosLuisa Rocha

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