Brain regeneration in Drosophila involves comparison of neuronal fitness

Current Biology : CB
Eduardo MorenoChrista Rhiner

Abstract

Darwinian-like cell selection has been studied during development and cancer [1-11]. Cell selection is often mediated by direct intercellular comparison of cell fitness, using "fitness fingerprints" [12-14]. In Drosophila, cells compare their fitness via several isoforms of the transmembrane protein Flower [12, 13]. Here, we studied the role of intercellular fitness comparisons during regeneration. Regeneration-competent organisms are traditionally injured by amputation [15, 16], whereas in clinically relevant injuries such as local ischemia or traumatic injury, damaged tissue remains within the organ [17-19]. We reasoned that "Darwinian" interactions between old and newly formed tissues may be important in the elimination of damaged cells. We used a model of adult brain regeneration in Drosophila in which mechanical puncture activates regenerative neurogenesis based on damage-responsive stem cells [20]. We found that apoptosis after brain injury occurs in damage-exposed tissue located adjacent to zones of de novo neurogenesis. Injury-affected neurons start to express isoforms of the Flower cell fitness indicator protein not found on intact neurons. We show that this change in the neuronal fitness fingerprint is required to rec...Continue Reading

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Citations

Apr 12, 2016·Communicative & Integrative Biology·Romain Levayer, Eduardo Moreno
Feb 24, 2016·Current Biology : CB·Romain LevayerEduardo Moreno
Jun 30, 2015·Neuroscience and Biobehavioral Reviews·Ismael Fernández-Hernández, Christa Rhiner
Apr 22, 2015·Current Biology : CB·Maximilien CourgeonClaude Desplan
Jun 21, 2016·Trends in Cell Biology·Marisa M MerinoEduardo Moreno
Aug 9, 2016·Annual Review of Cell and Developmental Biology·Cristina Clavería, Miguel Torres
Jul 3, 2019·Journal of Cell Science·Dina S Coelho, Eduardo Moreno
Feb 19, 2020·ELife·Guiyi LiAlicia Hidalgo
Jul 26, 2019·Nature·Esha MadanEduardo Moreno
Apr 8, 2020·Development·Donald T FoxRachel Smith-Bolton
Jun 24, 2017·Frontiers in Neuroscience·Anabel R Simões, Christa Rhiner
Sep 25, 2018·Frontiers in Physiology·Astrid Deryckere, Eve Seuntjens
May 3, 2020·International Journal of Molecular Sciences·Harris BolusStanislava Chtarbanova
Mar 3, 2021·Developmental Biology·Lorena Esteban-Martínez, Miguel Torres
Jun 13, 2021·Genetics·Kassi L CrockerGrace Boekhoff-Falk

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Methods Mentioned

BETA
transgenic
Dissection

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